Platelet Rich Fibrin in the Treatment of Palatal Wounds After Full Thickness Palatal Grafts Harvesting: A Randomized Clinical Trial
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Gingival Recession
- Sponsor
- G. d'Annunzio University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Time needed to obtain a complete re epithelialization of the palatal wound
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
In this study it will be investigated the usefulness of Platelet-Rich Fibrin (PRF) on in the full thickness palatal graft donor site healing acceleration and in the patient's morbidity reduction. Eighty patients, with at least one gingival recession will be treated by a flap with connective tissue graft(CTG). In the test group (20 patients) and in the control group 2 a quadruple layer of PRF membrane will be placed over the palatal wounds; conversely, the control groups 2-4 patients will be treated by an absorbable gelatin sponge. Patients will be monitored at 1, 2, 3 and 4 weeks after surgery for the complete re-epithelialization of the palatal wound (CWE), the alteration of sensibility (AS) around the wound area, the post-operative discomfort (D), and the changes of feeding habits (CFH) by a visual analogic scale (VAS) evaluation. Furthermore, the analgesics consumption and the existence of delayed bleeding from the palatal wound (DWB) during the first post-operative week will be assessed.
Detailed Description
In this study it will be investigated the usefulness of Platelet-Rich Fibrin (PRF) on in the full thickness palatal graft donor site healing acceleration and in the patient's morbidity reduction. Eighty patients, with at least one gingival recession will be treated by a coronally advanced flap (CAF) with connective tissue graft(CTG) resulting from the de-epithelialization of a free gingival graft. In the test group (20 patients) a quadruple layer of PRF membrane will be placed over the palatal wounds; conversely, the control groups patients will be treated by an absorbable gelatin sponge. Patients will be monitored at 1, 2, 3 and 4 weeks after surgery for the complete re-epithelialization of the palatal wound (CWE), the alteration of sensibility (AS) around the wound area, the post-operative discomfort (D), and the changes of feeding habits (CFH) by a visual analogic scale (VAS) evaluation. Furthermore, the analgesics consumption and the existence of delayed bleeding from the palatal wound (DWB) during the first post-operative week will be assessed.
Investigators
Michele Paolantonio
Head of Periodontology
G. d'Annunzio University
Eligibility Criteria
Inclusion Criteria
- •to have a single gingival recession to be treated by a mucogingival surgery intervention
- •to be in good systemic health
- •to have a good oral hygiene
Exclusion Criteria
- •no systemic diseases; no coagulation disorders; no medications affecting periodontal status in the previous 6 months; no pregnancy or lactation;
- •no smoking habits;
- •no periodontal surgery on the experimental sites;
- •no inadequate endodontic treatment
- •no tooth mobility at the site of surgery
Outcomes
Primary Outcomes
Time needed to obtain a complete re epithelialization of the palatal wound
Time Frame: 4 weeks
The primary outcome is to assess the time needed to obtain a complete re epithelialization of the palatal wound