Role of Platelet-Rich Fibrin in Intraoral Soft Tissue Regeneration of Head and Neck Surgery Patients: A Prospective Clinical Trial

University of Florida0 sitesSeptember 15, 2019

Overview

Phase: N/A
Intervention: Not specified
Conditions: Mucosal Ulceration
Sponsor: University of Florida
Primary Endpoint: Change in rate of healing in intraoral mucosa and epithelium soft tissues
Status: Withdrawn
Last Updated: 5 years ago

Determine if the use of platelet rich fibrin (PRF) improves the rate and quality of healing for intraoral mucosal and epithelial soft tissue defects.

Registry

clinicaltrials.gov

Start Date

September 15, 2019

End Date

August 3, 2020

Last Updated

5 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Sponsor

Responsible Party

Sponsor

•Three categories of patients will be included in this study:
•Osteoradionecrosis (ORN) or medication related osteonecrosis of the jaw (MRONJ) patients who present to clinic with exposed bone and no clinical sign of infection.
•Patients having an excisional biopsy in clinic performed under local anesthesia resulting in a defect that cannot be easily repaired without compromising normal anatomy or function. These situations include excisions which would result in primary closure under tension or with distorted anatomy, require a local flap, or require healing by secondary intention.
•Patients presenting to the post-operative clinic with intraoral surgical wound dehiscence or an intraoral surgical wound healing by secondary intention.

•Patients under 18 years of age.
•Patient's unable to participate in blood draw either due to medical compromise, inability to tolerate the procedure, or inability of the physician to successfully draw the blood at the time of appointment.