Title: Effect Of Injectable Platelet Rich Fibrin With Microneedling On Thin Gingival Phenotype In Fixed Non Extraction Orthodontic Cases - A Randomized Controlled Clinical Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Change in Gingival tissue thickness (GTT)
研究概览
简要总结
To evaluate the effect injectable platelet rich fibrin (i-PRF) along with microneedling on gingival thickness in patients with thin gingival phenotype undergoing non extraction fixed orthodontic treatment
详细描述
A non surgical, non invasive method of increasing gingival thickness has been reported using injectable platelet rich fibrin (i-PRF) alone and with microneedling (MN) in individuals with thin periodontal phenotype .
I-PRF is prepared as per low speed centrifugation concept that can provide a significant advantage for the regeneration process as it is rich in platelets, leukocytes, growth factors (As iprf is rich in WBC'c enabling slow and sustained release of growth factors as it clots and forms a gel approximately after 10-15 min and preserve its contents in the tissue for sustained release and inducing the expression of transforming growth factor-β11 and collagen-1 mRNA11, cellular fibroblasts11 and osteoblasts migration10 and collagen-1 synthesis10 .
Microneedling (MN) is also called as "percutaneous collagen induction therapy"9. Microinjuries created by MN result in minimal superficial bleedings and create a wound healing cascade which includes neocollagenesis and neoangiogenesis from which various growth factors, such as platelet derived growth factors, transforming growth factors, connective tissue growth factor and fibroblast growth factors are released9.
Primary therapeutic goal of this study is to do preorthodontic gingival augmentation using a latest technique injectable platelet rich fibrin (iprf) along with microneedling (MN) to increase the buccolingual thickness of marginal tissues over teeth that creates more robust marginal tissues that are less susceptible to trauma or plaque related inflammation and subsequent recession.
AIM : The primary aim of the study is to evaluate the effect injectable platelet rich fibrin (i-PRF) along with microneedling on gingival thickness in patients with thin gingival phenotype undergoing non extraction fixed orthodontic treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• GT of the mandibular anterior teeth <1mm (jepson et al. 2018) requiring labial orthodontic tooth movement without extraction.
- •Patients with > 18 years who will be systemically healthy
- •full-mouth plaque index (PI) and full-mouth bleeding on probing (BOP) score of ≤ 15%
- •gingival index (GI) of <1 (loe and silness) and dehiscence in mandibular anterior teeth detected in CBCT;
排除标准
- •Patients with thick gingival biotype (>1mm gingival thickness as per Jepson et al.,2018) ;
- •Patient undergoing dental extraction for labial orthodontic tooth movement.
- •previous periodontal surgery;
- •systemic disease;
- •use of blood thinners;
- •use of any drugs that might lead to gingival enlargement;
- •mucogingival stress, bruxism.
结局指标
主要结局
Change in Gingival tissue thickness (GTT)
时间窗: 6 months
Change in Gingival tissue thickness from baseline to 6 months
次要结局
未报告次要终点