Comparative Evaluation of Local Injectable Platelet Rich Fibrin and Hyaluronic Acid as Adjunctive to Non Surgical Periodontal Therapy: a Randomized Placebo Controlled Clinical Trial
Overview
- Phase
- N/A
- Intervention
- Platelet rich fibrin
- Conditions
- CHRONIC PERIODONTITIS
- Sponsor
- Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
- Enrollment
- 120
- Primary Endpoint
- Clinical attachment level (CAL)
- Last Updated
- 6 years ago
Overview
Brief Summary
Clinical evaluation of local subgingival application of injectable platelet-rich fibrin ( i-PRF ) for chronic periodntitis as adjunctive to non surgical therapy and compare it with hyaluronic acid.
120 periodontal patients will receive a scaling and root planing ( non surgical periodontal therapy). Equal number of patients will receive subgingival application of i-PRF, hyaluronic acid or placebo gel as the adjunction to non surgical therapy.
Detailed Description
The aim of the study is to evaluate and compare the clinical efficacy of subgingival application of i-PRF and hyaluronic acid gel as adjunctive to non-surgical periodontal therapy. 120 periodontal patients will receive traditional mechanical supra and subgingival scaling and root planing. Patients were randomly allocated in three groups. Group 1, 2 and 3 will receive subginigval application of placebo, hyaluronic acid gel and i prf respectively. Clinical parameters will be evaluated: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), gingival recession (GR). Clinical measurements will be performed at baseline, 1 month and at 3 months.
Investigators
ASHISH AGARWAL
Clinical professor, institute of dental sciences, bareilly
Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
Eligibility Criteria
Inclusion Criteria
- •Patients are in general good health.
- •Patients having minimum of 20 permanent teeth.
- •They have not taken medication known to interfere with periodontal tissue health or healing in the preceding 6 months.
- •Presence of periodontal pockets (≥5 mm) and clinicala ttachment level \> 5 mm.
Exclusion Criteria
- •Immunosuppressive systemic diseases (like cancer, AIDS, diabetes etc.)
- •Clotting and Hematological disorders
- •Patients with grade III mobility.
- •Patients with smoking and alcohol consuming habit.
- •Pregnant and lactating female.
- •Medications influence on the gingival and periodontal tissues (like calcium channel blockers, or Long-term steroid use)
- •The teeth with poor filling and ill fitted restorations
Arms & Interventions
Test group 2
injectable prf
Intervention: Platelet rich fibrin
Negative control
Placebo gel
Intervention: Placebo gel
Test group 1
Hyaluronic acid gel
Intervention: Hyaluronic acid gel
Outcomes
Primary Outcomes
Clinical attachment level (CAL)
Time Frame: 3 Months
Measure as the change in distance from the cementoenamel junction to the bottom of the gingival sulcus by using a periodontal probe (UNC 15 "University of North Carolina")
Secondary Outcomes
- Probing pocket depth(3 Months)