Comparison of Therapeutic Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- reduction of diameter of erythematous lesion under denture
研究概览
简要总结
The aim of the present study was to compare the effect of aqueous extract of garlic with nystatin mouthwash in denture stomatitis.
详细描述
Denture stomatitis is the most common form of chronic oral candidiasis manifested as chronic inflammation of the mucous membrane t supporting the movable prosthesis that may have a local or systemic nature. This inflammation is presented as mucous erythema and occasionally with pain and burning. The standard treatment for denture stomatitis is administration of nystatin which is accompanied with complications such as bitter taste as well as the high number of drug application that result in reduced tendency of patients in using this medication hence, efforts are continuously being made to substitute other types of therapies for this condition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •40 years of age and older
- •confirm of denture stomatitis by the oral medicine specialists
排除标准
- •Patients with a history of using anti-fungal drugs, antibiotics, and corticosteroid within the previous month
- •allergy to garlic and nystatin mouthwash
- •immunodeficiency
- •uncontrolled diabetes
- •those with garlic rich diet
- •inability in using mouthwash
- •loose and discolored dentures
- •psychologic disorder and alzheimer
研究组 & 干预措施
drug: garlic extract, nystatin
Drug: garlic extract 40mg/dl or nystatin suspension 100000 iu/ml tid for one month Patients had been clinically with denture stomatitis and confirmed by oral medicine specialist were selected for the study. Gender, age, medical history, erythema types, size, and other treatment used for this disease were recorded. Local ethical committee approval was obtained before the trial started and all patients gave written informed consent. Patients were randomly divided into two groups .First group received garlic extract and second group used nystatin suspension for 1 month. Each patients was examined at the beginning of the therapy ,and then every 1 weeks up to 1 months .
干预措施: garlic , nystatin (Drug)
结局指标
主要结局
reduction of diameter of erythematous lesion under denture
时间窗: first week
measuring erythematous lesion by visual and then photography and a colis
次要结局
- complete relief of erythematous lesions(fourth week)