Continuous Monitoring of Cerebral Energy State During Cardiac Surgery - A Novel Approach Utilizing Intravenous Microdialysis

Odense University Hospital1 site in 1 country10 target enrollmentFebruary 2015

ConditionsPostoperative; Dysfunction Following Cardiac Surgery

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Postoperative; Dysfunction Following Cardiac Surgery
Sponsor: Odense University Hospital
Enrollment: 10
Locations: 1
Primary Endpoint: Extracerebral microdialysis parameters
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by microdialysis (MD) of the cerebral venous outflow reflects a derangement of global cerebral energy state during cardiopulmonary bypass.

Detailed Description

Patients undergoing primary, elective coronary artery bypass grafting were blindly randomized to usual range MAP (40 to 60 mmHg; n = 5) or intervention group MAP (60 to 80 mmHg; n = 5) during CPB. MD catheters were positioned in a retrograde direction in the internal jugular vein and a reference catheter was inserted into the brachial artery. The relations between LP ratio, MAP, data obtained from bi-frontal NIRS and neurological outcome measures were assessed.

Registry

clinicaltrials.gov

Start Date

February 2015

End Date

May 2015

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Odense University Hospital

Responsible Party

Principal Investigator

Simon Mölström

Odense University Hospital

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Extracerebral microdialysis parameters

Time Frame: MD parameters were measured intraoperatively and for two hours postoperatively

Does the LP ratio of cerebral venous blood increase significantly during CPB indicating compromised cerebral oxidative metabolism.The analyses included the variables routinely monitored during intracerebral microdialysis: glucose, pyruvate, lactate, glutamate, glycerol and lactate to pyruvate ratio.