The Impact of Varying Exercise Training Intensity on Clinical Asthma Outcomes and Inflammation in Adults with Asthma
- Conditions
- AsthmaRespiratory - Asthma
- Registration Number
- ACTRN12617000991314
- Lead Sponsor
- Hunter Medical Research Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Stopped early
- Sex
- All
- Target Recruitment
- 46
1. Physician diagnosed asthma
2. Able to provide written informed consent
4. Body mass index (BMI) <=40kg/m2 (due to increased risk of exercise-related complication in those with a BMI >40kg/m2)
5. Not a current smoker (never smoker or quit at least 6 months ago)
6. Post-bronchodilator forced expiratory volume in 1 second (FEV1) >=50% predicted.
7. Deemed suitable for vigorous-intensity exercise by the study coordinator, according to the ESSA Adult Pre-Exercise Screening Tool”.
1. Asthma is not the primary respiratory diagnosis
2. A moderate exacerbation (oral corticosteroid or antibiotic use) in the past four weeks or
severe exacerbation (hospitalisation) in the past three months
3. Participation in a moderate- or vigorous-intensity exercise session within 2 days of the
scheduled study visits.
4. Known cardiac condition contraindicated for exercise
5. Musculoskeletal contraindication to exercise
6. Uncontrolled hypertension (blood pressure >180/100mmHg)
7. Cancer
8. Diabetes mellitus
9. Taking cholesterol lowering medication
10. Pregnancy or breastfeeding
11. Resting SpO2 <=95% on room air
12. Participation in an interventional research study in the last four weeks
13. Currently exercising at a moderate-intensity or greater for >90 mins/week
14. Subject has a clinically important medical illness (including serious psychological
disorders) likely to interfere with management or participation in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method