Biomarkers in Cardiology - BIC-15: False positive and negative Troponin values of point of care measurements in the Emergency Department

• Conditions: Troponin measurements from patients in the Emergency Department regardless what their chief complaints are.There is no need of specific chief complaints because the study does not aim at specific diseases.

• Registration Number: DRKS00004823
• Lead Sponsor: Charité - Universitätsmedizin BerlinMedizinische Klinik m.S. KardiologieArbeitsbereich Notfallmedizin CVK und CCM

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-11-30
• Study Start: 2015-04-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 4947

Inclusion Criteria

Patients in the Emergency Department that receive a Troponin measurement.

Exclusion Criteria

no exclusion criteria

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification of measurement discrepancies utilizing parallel measurement of cardiac troponin T and I performed on the POCT device used in the emergency department (EDTA, AQT-90, Radiometer) and high sensitive troponin T performed in the central laboratory (lithium-heparin, Cobas, Roche). All measurements are performed during regular patient treatment.

Secondary Outcome Measures

Name	Time	Method
Detection and quantification of possible sample mixups in troponin measurements in the emergency department using described thresholds and additional measurement od the two biomarkers total protein and pseudocholinesterase. All measurements are performed during regular patient treatment.<br>Additionally a comparison of the diagnostic accuracy of the troponin tests used will be performed concerning the diagnosis of acute myocardial infarction. Theses analyses will be performed after finalized recruitment.