Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study
- Conditions
- Cigarette SmokingNicotine Vaping
- Interventions
- Other: All nicotine/ tobacco products at market priceOther: Nicotine vaping products at 1/2 market priceOther: Heated tobacco products at 1/2 market price.Other: Nicotine pouch products at 1/2 market price.
- Registration Number
- NCT06456671
- Brief Summary
This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.
- Detailed Description
An important aim of tobacco control is to reduce demand for the most harmful products. Therefore, a priori knowledge of substitutability across novel and widely used tobacco products may forecast the impact of policies on product switching. This study will use a novel method, the Experimental Tobacco Marketplace (ETM), to characterize the relative substitutability and appeal (abuse liability) of tobacco products (e.g., conventional cigarettes, nicotine vaping products \[NVP\], heated tobacco products \[HTP\], and nicotine pouch products \[NPP\]), and how the appeal is modulated by relative price, user type, and regulatory environment. Exclusive cigarette smokers and dual cigarette/NVP users, stratified by age, will complete multiple scenarios in the ETM.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 456
- From CA, US, or EN
- At least 21 years old
- Smoking daily
- Smoking mostly or about equal amounts of factory-made cigarettes
- Does not currently vape (for exclusive smokers only)
- Vapes Daily (for dual users only)
- There will be no additional exclusion criteria for this study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Dual cigarette/ nicotine vaping product users Nicotine pouch products at 1/2 market price. Dual cigarette and nicotine vaping product users will be recruited and will be exposed to all of the conditions described in the intervention section. Dual cigarette/ nicotine vaping product users Nicotine vaping products at 1/2 market price Dual cigarette and nicotine vaping product users will be recruited and will be exposed to all of the conditions described in the intervention section. Dual cigarette/ nicotine vaping product users Heated tobacco products at 1/2 market price. Dual cigarette and nicotine vaping product users will be recruited and will be exposed to all of the conditions described in the intervention section. Exclusive cigarette smokers Heated tobacco products at 1/2 market price. Exclusive cigarette smokers will be recruited and will be exposed to all of the conditions described in the intervention section. Dual cigarette/ nicotine vaping product users All nicotine/ tobacco products at market price Dual cigarette and nicotine vaping product users will be recruited and will be exposed to all of the conditions described in the intervention section. Exclusive cigarette smokers All nicotine/ tobacco products at market price Exclusive cigarette smokers will be recruited and will be exposed to all of the conditions described in the intervention section. Exclusive cigarette smokers Nicotine vaping products at 1/2 market price Exclusive cigarette smokers will be recruited and will be exposed to all of the conditions described in the intervention section. Exclusive cigarette smokers Nicotine pouch products at 1/2 market price. Exclusive cigarette smokers will be recruited and will be exposed to all of the conditions described in the intervention section.
- Primary Outcome Measures
Name Time Method Cigarette demand 1 day Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will depend on the experimental condition. The degree to which other nicotine/tobacco products substitute for conventional cigarettes as a function of novel product (e.g. nicotine vaping products, heated tobacco products, nicotine pouch products) prices will be assessed.
To obtain dependent measures of demand, participants' purchasing of the price-manipulated commodity in the ETM task will be fit to a modified exponential equation to quantify the relationship between the price of each commodity and purchasing: Q=Q0\*10k(exp(-αQ0C)-1) where Q is purchasing of the commodity, C is the price, Q0 is the derived initial purchasing without cost constraints (demand intensity), k is the span of the function in logarithmic units, and α is the demand elasticity.Nicotine/tobacco products substitution 1 day Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will depend on the experimental condition. The degree to which other nicotine/tobacco products substitute for conventional cigarettes as a function of novel product (e.g. nicotine vaping products, heated tobacco products, nicotine pouch products) prices will be assessed.
To obtain estimates of substitution of price-constant products in the different ETM conditions, the investigators will use ordinary least squares regression to model the relationship of the price-manipulated product to predict total quantity purchased of the price-constant product.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fralin Biomedical Research Institute
🇺🇸Roanoke, Virginia, United States