Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)
- Conditions
- Electronic Cigarette Use
- Interventions
- Other: Tobacco product administration and assessment
- Registration Number
- NCT05971823
- Lead Sponsor
- Virginia Commonwealth University
- Brief Summary
The purpose of this study is to determine if abuse liability indices will be impacted by varying flavors and e-cigarette (ECIG) nicotine delivery capability (i.e., nicotine flux) among current combustible cigarette users.
The investigators will compare abuse liability indices between three FDA-authorized ECIG products that vary in nicotine flux (but are all tobacco flavor) and own brand cigarettes. The investigators will also test the influence of ECIG flavor availability (tobacco vs. menthol) within three ECIG product classes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- healthy (determined by self-report)
- at least 18 years old
- willing to provide informed consent
- able to attend the lab and use designated products according to study protocol
- smoke cigarettes at least 3 days per week and on those days at least 1 cigarette smoked per day
- positive urine cotinine test
- Women if they are breast-feeding or test positive for pregnancy (by urinalysis) at screening.
- Some study details about the eligibility criteria are purposely omitted at this time to preserve scientific integrity. Full details will be posted at the conclusion of the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description NJOY Daily 6.0% nicotine ECIG - Extra Rich Tobacco flavor Tobacco product administration and assessment - Own Brand Cigarette Tobacco product administration and assessment - NJOY Ace 2.4% nicotine ECIG - Classic Tobacco flavor Tobacco product administration and assessment - NJOY Ace 5.0% nicotine ECIG - Menthol flavor Tobacco product administration and assessment - NJOY Ace 5.0% nicotine ECIG - Classic Tobacco flavor Tobacco product administration and assessment - NJOY Daily 6.0% nicotine ECIG - Menthol flavor Tobacco product administration and assessment - NJOY Ace 2.4% nicotine ECIG - Menthol flavor Tobacco product administration and assessment -
- Primary Outcome Measures
Name Time Method Pmax of Drug Purchase Task (DPT) Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Intensity of Drug Purchase Task (DPT) Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Cross-price elasticity of the Cross Product-DPT Each CP-DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session The Cross Product (CP)-DPTs assess cross-product purchasing behaviors between various tobacco products offered at a fixed amount and own brand cigarettes offered at varying prices.
Breakpoint of Drug Purchase Task (DPT) Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Elasticity of Drug Purchase Task (DPT) Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Omax of Drug Purchase Task (DPT) A DPT will be Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session once for each arm. The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Center for the Study of Tobacco Products
🇺🇸Richmond, Virginia, United States