Normal Range of Superior Mesenteric Artery in Young Chinese Population and Its Correlation With Retroperitoneal Adipose Tissue

Completed

• Conditions: Retroperitoneal Adipose Tissue; Aortomesenteric Angle; Aortomesenteric Distance
• Interventions: Diagnostic Test: computerized tomography

• Registration Number: NCT03937193
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

In literature, superior mesenteric artery (SMA) angle, also named as aortomesenteric angle (AMA), varies greatly in both adult and children; while the aortomesenteric distance also ranges widely. Both AMA and AMD are influenced by retroperitoneal fat. Decrease of AMA and AMD may lead to the superior mesenteric artery syndrome(SMAS), which is a rare medical condition mainly presenting with duodenum obstruction. To our knowledge, normal range of AMA and AMD in local young Chinese population remain unclear; on the other hand, there have only a few studies exploring the relationship between them. This project proposes to establish the normal range of AMA and AMD in local young Chinese population, and to further investigate how the retroperitoneal adipose tissue correlates with AMA and AMD. The normal range obtained in this proposed study will provide more specific reference value to distinguish abnormal AMA and AMD, and to improve the diagnosis accuracy of SMAS in local population. Moreover, this study will provide deeper insight concerning the impact of retroperitoneal fat on AMA and AMD.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-05-02
• Study First Submitted QC: 2019-05-02
• Study First Posted: 2019-05-03
• Study Start: 2019-07-25
• Primary Completion: 2021-06-30
• Study Completion: 2021-06-30
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-17
• Last Update Posted: 2022-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 510

Inclusion Criteria

• With age range of 10-35 years old.
• Chinese ethnicity.
• With abdomen contrast CT.

Exclusion Criteria

• Any patients with diagnosis of SMAS will be excluded from the Non-SMAS group.
• Patients who had undergone more than one CT scan during the research period.
• Previous retroperitoneal, abdominal surgery.
• Conditions causing significant weight loss, e.g. anorexia nervosa, malabsorption.
• Presence of abdominal masses or pathology that will affect the anatomy of aorta- superior mesenteric artery and the retroperitoneal structures.
• Presence of severe scoliosis and/or history of spinal fixation that may increase incidence of SMA syndrome.
• Presence of free intraperitoneal or retroperitoneal fluid that may affect fat measurement, e.g. following trauma, or ascites.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
SMAS group	computerized tomography	subjects in this group are clinically diagnosed as superior mesenteric artery syndrome(SMAS).
Non-SMAS group	computerized tomography	subjects in this group are not clinically diagnosed as superior mesenteric artery syndrome(SMAS).

Primary Outcome Measures

Name	Time	Method
aortomesenteric angle (AMA)	2 years	aortomesenteric angle in degree measured on sagittal CT image
visceral fat area	2 years	visceral fat area in square centimeter(cm2) evaluated by image post-processing software
subcutaneous fat area	2 years	subcutaneous fat area in square centimeter(cm2) evaluated by image post-processing software
area ratio of visceral fat to subcutaneous fat	2 years	area ratio in percentage(%)
aortomesenteric distance (AMD)	2 years	aortomesenteric distance in millimeter(mm) on axial CT image

Trial Locations

Locations (1)

Department of Radiology， North District Hospital; 🇨🇳 Hong Kong, China