Birkebeiner II Study Investigating the Mechanisms of Atrial Fibrillation in Elderly Performing Endurance Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 395
- 试验地点
- 1
- 主要终点
- Changes in atrial function and presence of atrial fibrillation in veteran endurance athletes
研究概览
简要总结
Prolonged endurance exercise is associated with an elevated risk of atrial fibrillation (AF). The mechanisms governing this increased risk remains elusive. This study aim to detail the specific traits of elderly subjects with AF conducting endurance training by comparing elderly participators in the Birkebeiner cross country ski race(an indicator of prolonged endurance exercise practice) with and without AF to a not-so-trained control group.
详细描述
In recent years endurance sports with high intensity and participation in competition have been increasingly popular among middle aged and older people. The Birkebeiner studies are investigations of elderly non-professional athletes (65 years or older at enrollment in 2009/10) participating in the Birkebeiner cross-country ski race. It consists of Birkebeiner Aging Study, BIAS and the Birkebeiner Atrial Fibrillation, (BAF-study). The BAF-study investigated the association between prolonged endurance sport practice and the risk of AF by comparing the cohort of veteran cross-country skiers to a control population drawn from the Health and Environment Study in Oslo (HELMILO 2009).
The main findings of the Birkebeiner study so far have been that participation in the Birkebeiner cross-country ski race (an indicator of prolonged endurance exercise practice) is associated with an elevated risk of atrial fibrillation (AF) among men ≥ 65 years, and that this risk correlates with the cumulated amount of endurance-training. Similar findings were seen amongst female athletes. This increased risk of AF was shown independent of other known significant comorbidities (such as hypertension and diabetes), indicating that endurance-training at this level itself is an independent risk factor.
Regular physical exercise is an important factor when it comes to successful ageing. However, dose-relationship of physical exercise in a longer perspective is poorly studied. Atrial fibrillation is associated with increased risk of stroke, heart failure, dementia and death.
The mechanisms governing the increased risk of AF in elderly subjects undergoing endurance-training remains elusive. This study aim to detail the specific traits of elderly subjects with AF conducting endurance-training in comparison with trained and not-so-trained control groups. Thus, generating knowledge that can form the basis for better prevention and treatment of AF in this group.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 58 Years 至 83 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Already included in the Birkebeiner studies or "Health and environment study in Oslo" (HELMILO)
- •Born 1960 and earlier
排除标准
- •Born before
- •Earlier heart valve surgery.
- •MI (Mitral Insufficiency)≥ grade 3
- •Ejection Fraction (EF) <35%
结局指标
主要结局
Changes in atrial function and presence of atrial fibrillation in veteran endurance athletes
时间窗: Cross sectional study. Measured at time for inclusion.
2D strain (%) in the three phases of atrial function, measured by triplane echocardiography.
次要结局
- Changes in R-R variability (msec) in veteran endurance athletes(Cross sectional study. Measured at time for inclusion.)
- Presence of 171 genetic variants known to be associated with atrial fibrillation in veteran endurance athletes.(Cross sectional study. Measured at time for inclusion.)
- European Heart Rhythm Association (EHRA) score of atrial fibrillation related symptoms in veteran endurance athletes.(Cross sectional study. Measured at time for inclusion.)
- Changes in right ventricular volumes (ml) in veteran endurance athletes(Cross sectional study. Measured at time for inclusion.)
- Changes in p-wave (p-wave duration (msec), morphology and axis) in veteran endurance athletes(Cross sectional study. Measured at time for inclusion.)
- Changes in biochemical markers associated with atrial fibrosis and inflammation in veteran endurance athletes.(Cross sectional study. Measured at time for inclusion.)
研究者
Marit Aarønæs
Head of outpatient clinic, Marit Aaronaes, MD, PhD
Diakonhjemmet Hospital