ISRCTN42622771已完成未知
Effect of Aerobic Exercise and Low Carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men - the role of gut microbiota composition: a randomized interventional trial
Shanghai University of Sport (China)0 个研究点目标入组 115 人开始时间: 2013年4月23日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 115
研究概览
简要总结
2014 Protocol article in https://pubmed.ncbi.nlm.nih.gov/24438438/ protocol (added 23/10/2020) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35538056/ results of impact on gut microbiota (added 11/05/2022) 2017 Results article in https://pubmed.ncbi.nlm.nih.gov/29162875/ results of impact on hepatic fat content (HFC) and glycaemic control (added 11/05/2022)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Current inclusion criteria as of 02/02/2017:
- •1. Men or women aged 50-65 with fasting glucose between 5.6 to 6.9 mmol/ or glucose between 7.8 to 11.0 mmol/L after 2 hour in takes of glucose (75 g)
- •2. Have diagnosed non-alcoholic fatty liver disease (NAFLD) by 1H MRS (liver fat >5%)
- •3. For women, serum follicle-stimulating hormone level greater than 30 IU/L and last menstruation more than 6 months ago but within 10 years
- •Reference group 1:
- •1. Men or women aged 50-65 with fasting glucose between 5.6 to 6.9 mmol/L or glucose between 7.8 to 11.0 mmol/L after 2 hour in takes of glucose (75 g)
- •2. No NAFLD by MRS (<5%)
- •3. For women serum follicle-stimulating hormone level greater than 30 IU/L and last menstruation more than 6 months ago but within 10 years
- •Reference group 2:
- •1. Men or women aged 50-65 with fasting glucose below 5.6 mmol/L or glucose below 7.8 mmol/L after 2 hour in takes of glucose (75 g)
- •2. No NAFLD by MRS (<5%)
- •3. For women serum follicle-stimulating hormone level greater than 30 IU/L and last menstruation more than 6 months ago but within 10 years
- •Previous inclusion criteria:
- •1. Men or women aged 50-65 with fasting glucose between 5.6 to 6.9 mmol/ or glucose between 7.8 to 11.0 mmol/L after 2 hour in takes of glucose (75 g), and triglycerides > 1.7 mmol/L.
- •2. Have diagnosed non-alcoholic fatty liver disease (NAFLD) by 1H MRS (liver fat >5%).
- •3. For women, serum follicle-stimulating hormone level greater than 30 IU/L and last menstruation more than 6 months ago but within 10 years.
- •Reference group 1:
- •1. Men or women aged 50-65 with fasting glucose between 5.6 to 6.9 mmol/L or glucose between 7.8 to 11.0 mmol/L after 2 hour in takes of glucose (75 g), and triglycerides > 1.7 mmol/L
- •2. No NAFLD by MRS (<5%)
- •3. For women serum follicle-stimulating hormone level greater than 30 IU/L and last menstruation more than 6 months ago but within 10 years
- •Reference group 2:
- •1. Men or women aged 50-65 with fasting glucose below 5.6 mmol/L or glucose below 7.8 mmol/L after 2 hour in takes of glucose (75 g), and triglycerides < 1.7 mmol/L
- •2. No NAFLD by MRS (<5%)
- •3. For women serum follicle-stimulating hormone level greater than 30 IU/L and last menstruation more than 6 months ago but within 10 years
排除标准
- •1. BMI >38 kg/m2
- •2. Serious cardiovascular or musculoskeletal problems
- •3. Diagnosed Type 1 and 2 diabetes
- •4. Mental distraction
研究者
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