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Ribomustin in the Second Line Therapy of Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma

Completed
Conditions
Lymphoma, Non-Hodgkin
Interventions
Other: Ribomustin
Other: rituximab
Registration Number
NCT02072967
Lead Sponsor
Astellas Pharma Europe B.V.
Brief Summary

Prospective multicenter observational non-interventional study to assess routine clinical practice of Bendamustine use in the second line therapy of relapsed or refractory indolent B-cell non-Hodgkin's lymphoma

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
97
Inclusion Criteria
  • Doctor's decision to prescribe Ribomustin and rituximab combined therapy for the treatment of relapsed or refractory indolent B-cell Non-Hodgkin's Lymphoma (iNHL)
  • Informed Consent Form for personal data handling signed by the program participant, authorized by the Independent Ethics Committee
  • Eastern Cooperative Oncology Group (ECOG) status < 2.
  • Confirmed relapse or disease progression of B-cell CD20+ Non-Hodgkin's Lymphoma (lymphocytic, lymphocytoplasmocytic, follicular, marginal zone) after minimum one line of iNHL treatment
  • Patients with relapsed or refractory indolent B-cell Non-Hodgkin's Lymphoma with current or planned Ribomustin and rituximab combined therapy with following rituximab maintenance therapy
Exclusion Criteria
  • Indolent Non-Hodgkin's Lymphoma transformation
  • Lymphoma with central nervous system (CNS) involvement
  • Presence of second malignant tumor.
  • Currently participating in any clinical trial, and/or has taken an investigational drug within 28 days prior to enrollment.
  • Contraindications for Ribomustin usage in accordance with product label
  • Contradictions for rituximab usage in accordance with product label

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Ribomustin and rituximabRibomustin-
Ribomustin and rituximabrituximab-
Primary Outcome Measures
NameTimeMethod
Overall response rate90 days post-treatment
Secondary Outcome Measures
NameTimeMethod
Adverse drug reactionsup to 1 year

Trial Locations

Locations (35)

City Clinical Hospital #8

🇷🇺

Barnaul, Russian Federation

Chelyabinsk Regional Oncology Dispensary/15

🇷🇺

Chelyabinsk, Russian Federation

Vologda Regional Clinical Hospital #2

🇷🇺

Cherepovets, Russian Federation

Regional Oncology Dispensary/35

🇷🇺

Irkutsk, Russian Federation

Irkutsk Regional Сlinical Hospital/31

🇷🇺

Irkutsk, Russian Federation

Kaluga Regional Clinical Hospital/02

🇷🇺

Kaluga, Russian Federation

City Сlinical Hospital#7/25

🇷🇺

Krasnoyarsk, Russian Federation

District Cancer center od Khanty -Mansiysk

🇷🇺

Khanty-Mansiysk, Russian Federation

Adygei Regional Clinical Oncology Dispensary/11

🇷🇺

Maykop, Russian Federation

Regional Сlinical Hospital/12

🇷🇺

Krasnoyarsk, Russian Federation

European Medical Center

🇷🇺

Moscow, Russian Federation

Scientific Medical Surgical Center n.a.I.V.Pyrogov/17

🇷🇺

Moscow, Russian Federation

RONC n.a.N.N.Blokhin/18

🇷🇺

Moscow, Russian Federation

Сentral Clinical Hospital n.a. Semashko N.A./30

🇷🇺

Moscow, Russian Federation

Moscow Scientific Research Oncology Institution n.a.P.A. Gertzen/37

🇷🇺

Moscow, Russian Federation

Central Clinical Hospital of Department of Presidential Affairs

🇷🇺

Moscow, Russian Federation

Omsk Regional Clinical Hospital/40

🇷🇺

Omsk, Russian Federation

Medical Radiology Scientific Center/38

🇷🇺

Obninsk, Russian Federation

Novosibirsk State Regional Clinical Hospital/23

🇷🇺

Novosibirsk, Russian Federation

Municipal Сlinical Hospital № 12/20

🇷🇺

Nizhniy Novgorod, Russian Federation

Rostov Scientific Research Oncology Institution/01

🇷🇺

Rostov-on-Don, Russian Federation

City Сlinical Hospital#1 n.a.Kabanov A.N./13

🇷🇺

Omsk, Russian Federation

Orenburg State Medical Academy/05

🇷🇺

Orenburg, Russian Federation

City Сlinical Oncological Dispensary/22

🇷🇺

Saint-Petersburg, Russian Federation

City Сlinical Hospital#31/08

🇷🇺

Saint-Petersburg, Russian Federation

Military-Medical Academy n.a. Kirova

🇷🇺

Saint-Petersburg, Russian Federation

Samara State Medical University' Clinics/36

🇷🇺

Samara, Russian Federation

Scientific Research Oncological Institution n.a. Petrov N.N./29

🇷🇺

Saint-Petersburg, Russian Federation

Road Clinical Hospital on Rostov-Main Station OAO RZhD/06

🇷🇺

Smolensk, Russian Federation

Surgut Regional Clinical Hospital

🇷🇺

Surgut, Russian Federation

Volgograd Regional Clinical Oncology Dispensary#1/10

🇷🇺

Volgograd, Russian Federation

Vologda Regional Clinical Hospital/39

🇷🇺

Vologda, Russian Federation

Tula Regional Clinical Hospital/21

🇷🇺

Tula, Russian Federation

Yekaterinburg Regional Clinical Hospital #1

🇷🇺

Yekaterinburg, Russian Federation

Sakhalin Regional Oncology Dispensary/32

🇷🇺

Yuzhno-Sakhalinsk, Russian Federation

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