Magnetic Resonance Elastography of Myofascial Pain Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myofascial Pain
- Sponsor
- Mayo Clinic
- Enrollment
- 106
- Locations
- 1
- Primary Endpoint
- The fascia plane mobility assessed by MR Elastography-based normalized octahedral shear strain (NOSS) measurements
- Status
- Enrolling By Invitation
- Last Updated
- 6 months ago
Overview
Brief Summary
The purpose of this research study is to use a new imaging technique called Magnetic Resonance (MR) Elastography to create new imaging parameters to measure the mechanical properties of myofascial tissues that can be used to assess the impaired myofascial interface in myofascial pain syndrome (MPS).
Detailed Description
This is observational research that aims to develop an MRI-based imaging technique (MRE) to quantitatively assess the myofascial tissue properties in healthy subjects and patients with relevant pain conditions. Healthy volunteers and patients with MPS will be recruited to undergo MRI along with MR elastography.
Investigators
Ziying Yin
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Absence of a history of chronic pain in the targeted anatomical location (i.e., lower back and low extremities) that had limited activities of daily living or work
- •A numerical current pain index of less than 0.5 (on a 10-point Visual Analog Scale)
- •Able to understand the goal of the project and give informed consent.
- •Healthy Volunteer
Exclusion Criteria
- •Pregnancy or breastfeeding
- •Any contraindication to an MRI exam
- •Previous severe/acute back or low extremity injury (including fracture)
- •Previous back or low extremity surgery
- •Back and lower limb deformities
- •Inability to provide consent.
- •Myofascial-Related Pain Patient Inclusion Criteria:
- •A history of chronic low back or leg pain (the targeted location will be determined based on the findings in Aim 1) for at least 3 months. (Measured by patient history and physical exam)
- •A palpable taut band or nodule within the skeletal muscle
- •Hypersensitive tender spot within the taut band
Outcomes
Primary Outcomes
The fascia plane mobility assessed by MR Elastography-based normalized octahedral shear strain (NOSS) measurements
Time Frame: baseline measures through the study completion (3 years)
In response to an external shear force, the fascial layers that surround and separate muscles can deform or slide relative to each other, depending on the fascial plane's mobility. An adhesive interface that experiences a shear force will exhibit shear displacement continuity (i.e., small shear strain) across the interface, while a nonadhesive interface may slip rather than deform, which causes a discontinuity in displacement (i.e., large shear strain). For the targeted fascia plane in low back and legs, the normalized octahedral shear strain (NOSS) will be computed from the shear displacement data measured from MRE to assess the fascia plane mobility. The primary outcome measure is the difference in the fascia plane mobility on MR elastography between patients with myofascial-related pain diseases and healthy controls without myofascial-related pain diseases.