ACTRN12624000270516尚未招募4 期
The effect of substantial weight loss with tirzepatide on heart failure with preserved ejection fraction in people with obesity
适应症
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •Are greater than 18 years old,
- •Have a BMI of 30 or more, or a BMI of 27 or more and at least one weight-related complication (e.g., hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease),
- •Report one or more unsuccessful dietary effort to lose weight.
排除标准
- •Change in body weight of more than 5 kg within 90 days before screening
- •Previous or planned surgical treatment for obesity
- •Treatment with a medication that promotes weight loss within 90 days before screening
- •Ejection fraction <50% (current or prior)
- •Significant valvular heart disease (greater than mild stenosis, greater than moderate regurgitation)
- •Pulmonary arterial hypertension
- •Constrictive pericarditis
- •Primary cardiomyopathies
- •Heart transplantation
- •Significant pulmonary disease
- •History of pancreatitis
- •Previous bariatric surgery
- •Diagnosis of gastroparesis
- •Diagnosis of cancer within the past 5 years (excluding skin cancers)
- •Personal or family history of medullary thyroid cancer
- •Patients not eligible for Medicare
- •Patients who are not fluent in English.
研究者
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