Characterization of Retinal Microvascular and FAZ Changes in Ischemic Stroke and Its Different Types
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Vascular Area Density(VAD)
Study Overview
Brief Summary
The study aimed to access the microvascular changes in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in patients with ischemic stroke and its different types using optical coherence tomography angiography.
Detailed Description
Investigators used OCTA to quantitatively access the retinal microvasculature of SCP and DCP, aiming to detect the geometry changes of retinal microvasculature and FAZ in ischemic stroke patients and its different types.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 40 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients who were diagnosed with ischemic stroke by MRI were scheduled for an OCTA examination. The diagnosis of ischemic stroke was obtained from previous diagnostic reports or electronic medical records, according to the diagnostic criteria from the Trial of Org 10172 in Acute Stroke Treatment (TOAST).
Exclusion Criteria
- •Retinal diseases or diseases affecting vessel structure in fundus photography, including age-related maculopathy; diabetic retinopathy, central serous chorioretinopathy, retinal pigment epithelial detachment and glaucoma); poor cooperation in ophthalmic examinations; high refractive error (>+6.00 D or <-6.00 D Spherical Equivalent); low-quality OCTA images (signal strength index < 6/10). Inclusion criteria for healthy controls were no history of ischemic stroke or other neurological and ocular diseases.
Outcomes
Primary Outcomes
Vascular Area Density(VAD)
Time Frame: immediately after meeting the inclusion and exclusion criteria
The total length in millimeters of perfused retinal microvasculature per unit area in square millimeters in the annular region of analyzed area
FAZ Area(FA)
Time Frame: immediately after meeting the inclusion and exclusion criteria
The total numbers of pixels in the FAZ region
FAZ Axis Ratio(FAR)
Time Frame: immediately after meeting the inclusion and exclusion criteria
The ratio between the major and minor axes of the fitted ellipse from the FAZ boundary. The axis ratio of a perfect circular FAZ is equal to 1
Vascular Orientation Distribution(VOD)
Time Frame: immediately after meeting the inclusion and exclusion criteria
The direction of each vascular pixel to indicate the trend of the blood flow
Vascular Fractal Dimension(VFD)
Time Frame: immediately after meeting the inclusion and exclusion criteria
A well-known parameter which indicates the degree of geometric complexity of vasculature
FAZ Circularity(FC)
Time Frame: After meeting the inclusion and exclusion criteria
The ratio of the perimeter of the FAZ to the parameter of a circle with equal area, reflecting the degree of roundness of the FAZ
FAZ Roundness(FR)
Time Frame: immediately after meeting the inclusion and exclusion criteria
Similar to FC, but is less sensitive to irregular borders along the parameter of FAZ
Secondary Outcomes
No secondary outcomes reported