OCTA and Retinal Angiomatous Proliferation

Completed

• Conditions: Age Related Macular Degeneration

• Registration Number: NCT04689789
• Lead Sponsor: Federico II University

Brief Summary

To investigate, using optical coherence tomography angiography, the retinal vascular features in patients affected by RAP.

Detailed Description

Retinal vascular anomalous complex represents a distinct form of neovascularization in patients with age-related macular degeneration.

The study investigated the changes in retinal vascular network using optical coherence tomography angiography, a novel and non invasive diagnostic technique that allows to better understand the pathophysiologic mechanism of this neovascularization.

Study Timeline

• Study Start: 2019-09-01
• Status Verified: 2020-12
• Primary Completion: 2020-12-01
• Study Completion: 2020-12-20
• Study First Submitted: 2020-12-29
• Study First Submitted QC: 2020-12-29
• Last Update Submitted: 2020-12-29
• Study First Posted: 2020-12-30
• Last Update Posted: 2020-12-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

• age older than 65 years
• diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
• absence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
• absence of significant lens opacities, low-quality OCT-A images.

Exclusion Criteria

• age older than 80 years
• absence of diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
• presence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
• presence of significant lens opacities, low-quality OCT-A images.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The measurements of retinal vascular network in patients with age-related macular degeneration, using optical coherence tomography angiography, compared to controls	15 months	The parameters analyzed by optical coherence tomography angiography were: vessel density of superficial capillary plexus and deep capillary plexus

Trial Locations

Locations (1)

Federico II University; 🇮🇹 Naples, Napoli, Italy