The Role of Quantitative Deep Capillary Plexus in the Pathogenesis of Retinal Angiomatous Proliferation: an Optical Coherence Tomography Angiography Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 118
- 试验地点
- 1
- 主要终点
- The measurements of retinal vascular network in patients with age-related macular degeneration, using optical coherence tomography angiography, compared to controls
研究概览
简要总结
To investigate, using optical coherence tomography angiography, the retinal vascular features in patients affected by RAP.
详细描述
Retinal vascular anomalous complex represents a distinct form of neovascularization in patients with age-related macular degeneration.
The study investigated the changes in retinal vascular network using optical coherence tomography angiography, a novel and non invasive diagnostic technique that allows to better understand the pathophysiologic mechanism of this neovascularization.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age older than 65 years
- •diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
- •absence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- •absence of significant lens opacities, low-quality OCT-A images.
排除标准
- •age older than 80 years
- •absence of diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
- •presence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- •presence of significant lens opacities, low-quality OCT-A images.
结局指标
主要结局
The measurements of retinal vascular network in patients with age-related macular degeneration, using optical coherence tomography angiography, compared to controls
时间窗: 15 months
The parameters analyzed by optical coherence tomography angiography were: vessel density of superficial capillary plexus and deep capillary plexus
次要结局
未报告次要终点
研究者
Gilda Cennamo
Principal Investigator
Federico II University