Retinal and Choriocapillaris Vascular Features in Patients With Beta Thalassemia by Means of Optical Coherence Tomography Angiography
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thalassemia
- Sponsor
- Federico II University
- Enrollment
- 82
- Locations
- 1
- Primary Endpoint
- The measurements of retinal and choriocapillaris features in patients with Beta Thalassemia, using optical coherence tomography angiography.
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
To investigate, using optical coherence tomography angiography (OCTA), the retinal and choriocapillaris vascular features in patients affected by Beta Thalassemia. Moreover we analyzed the structural retinal parameters (ganglion cell complex and retinal nerve fiber layer), using optical coherence tomography (OCT) in these patients
Detailed Description
Beta Thalassemia is one of the most common genetic hemoglobinopathy characterized by a defective β globulin chain synthesis leading to hemolysis and ineffective erythropoiesis. The study investigated the changes in retinal and choriocapillaris vascular features using optical coherence tomography angiography, a novel and noninvasive diagnostic technique that allows a detailed analysis of retinal and choriocapillaris blood flow.
Investigators
Gilda Cennamo
Principal Investigator
Federico II University
Eligibility Criteria
Inclusion Criteria
- •age older than 35 years
- •diagnosis of Beta Thalassemia
- •absence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- •absence of significant lens opacities, low-quality OCT and OCT-A images.
Exclusion Criteria
- •age older than 50 years
- •absence of diagnosis of Beta Thalassemia
- •presence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- •presence of significant lens opacities, low-quality OCT and OCT-A images.
Outcomes
Primary Outcomes
The measurements of retinal and choriocapillaris features in patients with Beta Thalassemia, using optical coherence tomography angiography.
Time Frame: Four months
The parameters analyzed by optical coherence tomography angiography were: retinal and choriocapillaris vessel density
Secondary Outcomes
- The measurements of retinal structural parameters in patients with Beta Thalassemia, using optical coherence tomography.(Four months)