Sarcopenia and Peripheral Artery Disease With Chronic Limb Threatening Ischemia

Completed

• Conditions: Sarcopenia; Peripheral Arterial Disease; Chronic Limb Threatening Ischemia

• Registration Number: NCT07037979
• Lead Sponsor: Fudan University

Brief Summary

To evaluate the correlation of Sarcopenia Parameters and Peripheral Artery Disease with chronic limb threatening ischaemia.

Detailed Description

Prior researches indicated a relatively high prevalence of sarcopenia among patients of Peripheral Artery Disease. However, the relationship between sarcopenia and progression of Peripheral Artery Disease with chronic limb threatening ischaemia remained poorly understood. Thus, this cohort study aimed to evaluate the correlation of Sarcopenia Parameters, such as psoas muscle area (PMA) and total abdominal muscle area (TAMA) at the L3 vertebral level, measured by computed tomography (CT), and progression of Peripheral Artery Disease with chronic limb threatening ischaemia.

Study Timeline

• Study Start: 2023-01-01
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31
• Status Verified: 2025-06
• Study First Submitted: 2025-06-05
• Study First Submitted QC: 2025-06-24
• Last Update Submitted: 2025-06-24
• Study First Posted: 2025-06-26
• Last Update Posted: 2025-06-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 97

Inclusion Criteria

• Patients of Peripheral Artery Disease, including intermittent claudication and Chronic Limb Threatening Ischemia;
• Patients with Rutherford grade 2-6 between Jan.1 2023 and Dec.31 2024;
• Patients at age 18-80;
• Patients underwent an in-hospital routine enhanced whole abdomen to lower extremities CT scan;
• Patients able to complete the clinical follow-up for 3 months.

Exclusion Criteria

• Poor CT quality or incomplete images;
• Incomplete clinical data;
• In-hospital mortality during Jan.1 2023 and Dec.31 2024.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
psoas muscle area (PMA) [measured by computed tomography (CT)]	2023.1.1～2024.12.31	psoas muscle area (PMA) (square centimeters) was regarded as a kind of typical sarcopenia parameters, measured by computed tomography (CT) at the L3 vertebral level
total abdominal muscle area (TAMA) measured by computed tomography (CT)	2023.1.1～2024.12.31	total abdominal muscle area (TAMA) (square centimeters) was regarded as a kind of typical sarcopenia parameters, measured by computed tomography (CT) at the L3 vertebral level

Trial Locations

Locations (1)

Huadong Hospital, Fudan University; 🇨🇳 Shanghai, China