A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment

Registration Number
NCT06105632
Lead Sponsor
Pfizer
Brief Summary

The purpose of this study is to learn about the safety and how effective the study medicine (PF-07220060) plus fulvestrant is compared to the study doctor's choice of treatment in people with advanced or metastatic breast cancer. Advanced cancer is the one that is unlikely to be cured or taken care of with treatment. Metastatic cancer is the one that has spr...

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
500
Inclusion Criteria
  • Histological confirmation of breast cancer with evidence of locally advanced or metastatic disease, which is not amenable to surgical resection or radiation therapy with curative intent.
  • Documented estrogen receptor (ER) and/or progesterone receptor (PR)- positive tumor
  • Documented HER2-negative tumor
  • Able to provide a sufficient amount of representative formalin fixed, paraffin embedded (FFPE) tumor tissue specimen.
  • Must have received CDK4/6i plus NSAI defined per study protocol. There must be documented PD during or after CDK4/6i treatment.
  • Measurable disease or non-measurable bone only disease as defined by RECIST version 1.1.
  • Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤2.
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Exclusion Criteria
  • Any medical or psychiatric condition that may increase the risk of study participation or make the participant inappropriate for the study.
  • In visceral crisis at risk of immediately life-threatening complications in the short term.
  • Known active uncontrolled or symptomatic central nervous system metastases, carcinomatous meningitis, or leptomeningeal disease.
  • Prior treatment with any of the following:
  • Everolimus or investigational anti-cancer agents in any setting
  • Prior chemotherapy in the advanced setting
  • Radiation within 2 weeks of randomization
  • Current use or anticipated need for any prohibited food, supplements or concomitant medication(s) (ie, other anti-cancer therapies, other endocrine therapies, growth factors, chronic systemic corticosteroids, strong cytochrome P450 3A4/5 [CYP3A4/5] or uridine 5' diphosphate-glucuronosyltransferase 2B7 [UGT2B7] inhibitors and inducers, direct oral anticoagulants, proton pump inhibitors).
  • Inadequate renal function, hepatic dysfunction, or hematologic abnormalities.
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Arm APF-07220060 CDK4 inhibitorPF-07220060 to be taken by mouth as a tablet in combination with fulvestrant (a solution for injection)
Arm BFulvestrantInvestigator's choice of therapy of either: * Fulvestrant alone (a solution for injection), or * Everolimus in combination with exemestane, both a tablet to be taken by mouth.
Arm AFulvestrantPF-07220060 to be taken by mouth as a tablet in combination with fulvestrant (a solution for injection)
Arm BEverolimusInvestigator's choice of therapy of either: * Fulvestrant alone (a solution for injection), or * Everolimus in combination with exemestane, both a tablet to be taken by mouth.
Arm BExemestaneInvestigator's choice of therapy of either: * Fulvestrant alone (a solution for injection), or * Everolimus in combination with exemestane, both a tablet to be taken by mouth.
Primary Outcome Measures
NameTimeMethod
Progression-Free Survival (PFS) progression, as determined by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1From Initiation up to 2 years
Secondary Outcome Measures
NameTimeMethod
PFS as defined by investigatorTime from the date of randomization up to approximately 2 years
Overall Survival (OS)Time from the date of randomization to the date of death due to any cause up to approximately 5 years
Duration of Response (DOR) as define by Blinded Independent Central Review (BICR) and by investigator per RECIST v1.1From the date of the first objective response (every 8 weeks during the first 48 weeks and then every 12 week) up to approximately 2 years.
Number or Patients with Adverse Events (AEs) by TypeFrom screening until 28 days after the last dose, to approximately 3 years
Number or Patients with AEs by SeriousnessFrom screening until 28 days after the last dose, to approximately 3 years
EORTC QLQScreening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc), EoT and Safety FU until 28 days after the last dose to approximately 2 years. Each Cycle is 28 days
Ctrough of PF-07220060Cycle 1 (Day 15), Cycle 2 (Day 1), and Cycle 3 (Day 1). Each Cycle is 28 days
OR by BICR and by investigator per RECIST v1.1Time From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) to the date of progression OR death whichever occurs first (up to approximately 2 years)
Number of Participants With Clinical Benefit Response (CBR) by BICR and by investigator per RECIST v1.1From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) up to approximately 2 years
Number or Patients with AEs by IncidenceFrom screening until 28 days after the last dose, to approximately 3 years
Number or Patients with AEs by relationship to study interventionsFrom screening until 28 days after the last dose, to approximately 3 years
Number of Participants With Abnormal Electrocardiogram (ECG)From baseline to approximately 2 years
EORTC QLQ Breast Cancer Module 23 (BR23)Screening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc), EoT and Safety FU until 28 days after the last dose to approximately 2 years. Each Cycle is 28 days
Number of Participants With Laboratory Test AbnormalitiesFrom screening until 28 days after the last dose to approximately 2 years
EQ-5D-5LScreening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc), EoT and Safety FU until 28 days after the last dose to approximately 2 years. Each Cycle is 28 days

Trial Locations

Locations (226)

Highlands Oncology Group

🇺🇸

Springdale, Arkansas, United States

CHU de Québec-Université Laval, Hôpital du Saint-Sacrement

🇨🇦

Quebec City, Quebec, Canada

Anhui Provincial Cancer Hospital

🇨🇳

Hefei, Anhui, China

Shizuoka Cancer Center

🇯🇵

Nagaizumi-cho,Sunto-gun, Shizuoka, Japan

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

🇹🇷

Istanbul, İ̇stanbul, Turkey

UCSF - John Muir Health Cancer Center Berkeley

🇺🇸

Berkeley, California, United States

Washington Hospital Healthcare System

🇺🇸

Fremont, California, United States

Hoag Health Center Irvine

🇺🇸

Irvine, California, United States

Eisenhower George and Julia Argyros Health Center

🇺🇸

La Quinta, California, United States

Hoag Hospital Irvine

🇺🇸

Irvine, California, United States

Keck Hospital of USC

🇺🇸

Los Angeles, California, United States

Los Angeles General Medical Center

🇺🇸

Los Angeles, California, United States

USC/Norris Comprehensive Cancer Center

🇺🇸

Los Angeles, California, United States

Advocate Good Shepherd Hospital

🇺🇸

Barrington, Illinois, United States

Northwestern Memorial Hospital

🇺🇸

Chicago, Illinois, United States

Bon Secours at St. Mary's Hospital

🇺🇸

Richmond, Virginia, United States

Bon Secours St. Francis Medical Center

🇺🇸

Midlothian, Virginia, United States

Swedish Cancer Institute

🇺🇸

Seattle, Washington, United States

Swedish Medical Center

🇺🇸

Seattle, Washington, United States

Aurora Health Center - Southern Lakes

🇺🇸

Burlington, Wisconsin, United States

Aurora Medical Centers - Grafton

🇺🇸

Grafton, Wisconsin, United States

Aurora BayCare Medical Center

🇺🇸

Green Bay, Wisconsin, United States

Aurora Health Center Milwaukee - Good Hope

🇺🇸

Milwaukee, Wisconsin, United States

Aurora Health Center - Kenosha

🇺🇸

Kenosha, Wisconsin, United States

Aurora St Luke's Medical Center

🇺🇸

Milwaukee, Wisconsin, United States

Aurora Medical Center - Summit

🇺🇸

Summit, Wisconsin, United States

Aurora Cancer CAre

🇺🇸

Wauwatosa, Wisconsin, United States

Centro de Investigaciones Metabólicas (CINME)

🇦🇷

Ciudad Autónoma De Buenos Aires, Ciudad Autónoma D, Buenos Aires, Argentina

CIPREC

🇦🇷

Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Fundación Cenit Para La Investigación En Neurociencias

🇦🇷

Caba, Ciudad Autónoma DE Buenos Aires, Argentina

Hospital Mae de Deus

🇧🇷

Porto Alegre, RIO Grande DO SUL, Brazil

Fundação Pio XII - Hospital de Câncer de Barretos

🇧🇷

Barretos, SÃO Paulo, Brazil

Centro de Oncologia - CEON+ - Unidade São Caetano do Sul

🇧🇷

São Caetano do Sul, SÃO Paulo, Brazil

Ajou University Hospital

🇰🇷

Suwon-si, Kyǒnggi-do, Korea, Republic of

National Taiwan University Hospital

🇨🇳

Taipei, Taiwan

Mackay Memorial Hospital

🇨🇳

Taipei, Taiwan

Taipei Veterans General Hospital

🇨🇳

Taipei, Taiwan

Koo Foundation Sun Yat-Sen Cancer Center

🇨🇳

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch

🇨🇳

Taoyuan, Taiwan

Medipol Mega Universite Hastanesi

🇹🇷

Stanbul, İ̇stanbul, Turkey

Acibadem Altunizade Hospital

🇹🇷

Üsküdar / Stanbul, İ̇stanbul, Turkey

Ege Universitesi Hastanesi

🇹🇷

Izmir, İ̇zmir, Turkey

Gulhane Egitim Arastirma Hastanesi

🇹🇷

Ankara, Turkey

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi

🇹🇷

Ankara, Turkey

Hacettepe Universite Hastaneleri

🇹🇷

Ankara, Turkey

Ultramar Medical Imaging Center

🇹🇷

Ankara, Turkey

Memorial Ankara Hastanesi

🇹🇷

Ankara, Turkey

Ankara Bilkent Şehir Hastanesi

🇹🇷

Ankara, Turkey

Necmettin Erbakan Meram Medical Fac.

🇹🇷

Konya, Turkey

Dicle Üniversitesi

🇹🇷

Diyarbakir, Turkey

Erciyes Universitesi Tıp Fakultesi Hastaneleri

🇹🇷

Kayseri, Turkey

Kocaeli Üniversitesi

🇹🇷

Kocaeli, Turkey

Samsun Medical Park Hastanesi

🇹🇷

Samsun, Turkey

The Princess Alexandra Hospital NHS Trust

🇬🇧

Harlow, England, United Kingdom

The Royal Cornwall Hospital

🇬🇧

Truro, England, United Kingdom

Imperial College Healthcare NHS Trust, Charing Cross Hospital

🇬🇧

London, Hammersmith AND Fulham, United Kingdom

Sarah Cannon Research Institute UK

🇬🇧

London, London, CITY OF, United Kingdom

University Hospital Coventry & Warwickshire

🇬🇧

Coventry, Warwickshire, United Kingdom

Western General Hospital

🇬🇧

Edinburgh, Midlothian, United Kingdom

The Royal Surrey County Hospital

🇬🇧

Guildford, United Kingdom

The Christie NHS Foundation Trust

🇬🇧

Manchester, United Kingdom

Great Western Hospital

🇬🇧

Swindon, United Kingdom

Jilin Province Tumor Hospital

🇨🇳

Changchun, Jilin, China

Jiangsu Province Hospital

🇨🇳

Nanjing, Jiangsu, China

Hoag Memorial Hospital Presbyterian

🇺🇸

Newport Beach, California, United States

Eisenhower Health Center at South Palm Canyon

🇺🇸

Palm Springs, California, United States

Keck Medical Center of USC Pasadena

🇺🇸

Pasadena, California, United States

Eisenhower Medical Center

🇺🇸

Rancho Mirage, California, United States

Zuckerberg San Francisco General Hospital and Trauma Center

🇺🇸

San Francisco, California, United States

UCSF Medical Center at Mission Bay

🇺🇸

San Francisco, California, United States

UCSF Cancer Center San Mateo

🇺🇸

San Mateo, California, United States

Chronic Disease Clinical Research Center (CDCRC)

🇺🇸

Torrance, California, United States

Clinical and Translational Research Center

🇺🇸

Torrance, California, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

🇺🇸

Torrance, California, United States

Diagnostic and Wellness Center

🇺🇸

Torrance, California, United States

Harbor UCLA

🇺🇸

Torrance, California, United States

Saint Vincent's Medical Center (SVMC)

🇺🇸

Bridgeport, Connecticut, United States

Danbury Hospital

🇺🇸

Danbury, Connecticut, United States

Hartford Hospital (HH)

🇺🇸

Hartford, Connecticut, United States

MidState Medical Center (MMC)

🇺🇸

Meriden, Connecticut, United States

Hartford Healthcare

🇺🇸

New Britain, Connecticut, United States

Norwalk Hospital

🇺🇸

Norwalk, Connecticut, United States

Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut, Medical Arts Center

🇺🇸

Plainville, Connecticut, United States

Georgetown University Medical Center

🇺🇸

Washington, District of Columbia, United States

MedStar Washington Hospital Center

🇺🇸

Washington, District of Columbia, United States

Summit Cancer Care DBA Candler Medical Oncology Practice

🇺🇸

Savannah, Georgia, United States

Summit Cancer Care, PC

🇺🇸

Savannah, Georgia, United States

NorthShore University HealthSystem

🇺🇸

Highland Park, Illinois, United States

Advocate Illinois Masonic Medical Center

🇺🇸

Chicago, Illinois, United States

Advocate Good Samaritan Hospital

🇺🇸

Downers Grove, Illinois, United States

Ascension Illinois - Evanston Infusion Center

🇺🇸

Evanston, Illinois, United States

AMG Libertyville

🇺🇸

Libertyville, Illinois, United States

Advocate Christ Medical Center

🇺🇸

Oak Lawn, Illinois, United States

Advocate Lutheran General Hospital

🇺🇸

Park Ridge, Illinois, United States

Ascension Illinois-Skokie Infusion Center

🇺🇸

Skokie, Illinois, United States

Orchard Healthcare Research Inc.

🇺🇸

Skokie, Illinois, United States

University of Iowa Health Care Cancer Services Quad Cities

🇺🇸

Bettendorf, Iowa, United States

University of Iowa Hospitals & Clinics

🇺🇸

Iowa City, Iowa, United States

Anne Arundel Medical Center

🇺🇸

Annapolis, Maryland, United States

The University of Mississippi Medical Center

🇺🇸

Jackson, Mississippi, United States

Intermountain Health St. Vincent Regional Hospital

🇺🇸

Billings, Montana, United States

St. Vincent Frontier Cancer Center

🇺🇸

Billings, Montana, United States

Cancer Care Specialists

🇺🇸

Reno, Nevada, United States

Hackensack University Medical Center

🇺🇸

Hackensack, New Jersey, United States

John Theurer Cancer Center at Hackensack University Medical Center

🇺🇸

Hackensack, New Jersey, United States

Vassar Brothers Medical Center

🇺🇸

Poughkeepsie, New York, United States

SUNY Upstate Medical University

🇺🇸

Syracuse, New York, United States

Memorial Hermann Cancer Center

🇺🇸

Houston, Texas, United States

Baylor Scott & White Medical Center - Round Rock

🇺🇸

Round Rock, Texas, United States

Bon Secours Memorial Regional Medical Center

🇺🇸

Mechanicsville, Virginia, United States

Organizacion Medica de Investigacion

🇦🇷

Caba, Ciudad Autónoma DE Buenos Aires, Argentina

Hospital Británico de Buenos Aires

🇦🇷

Caba, Ciudad Autónoma DE Buenos Aires, Argentina

Clinica Viedma S. A

🇦🇷

Viedma, RÍO Negro, Argentina

Instituto de Oncología de Rosario

🇦🇷

Rosario, Santa FE, Argentina

Sanatorio de La Mujer

🇦🇷

Rosario, Santa FE, Argentina

Centro Para la Atención Integral del Paciente Oncologico (CAIPO)

🇦🇷

San Miguel de Tucuman, Tucumán, Argentina

Exelsus - Oncología Clínica

🇦🇷

San Miguel de Tucumán, Tucumán, Argentina

Fundación Respirar

🇦🇷

Ciudad Autónoma Buenos Aires, Argentina

Centro Medico Austral

🇦🇷

Ciudad Autónoma de Buenos Aires, Argentina

Clínica Universitaria Reina Fabiola

🇦🇷

Córdoba, Argentina

Fundación CORI para la Investigación y Prevención del Cáncer

🇦🇷

La Rioja, Argentina

Sanatorio Norte

🇦🇷

Santiago del Estero, Argentina

Macquarie University

🇦🇺

North Ryde, New South Wales, Australia

Icon Cancer Centre Townsville

🇦🇺

Townsville, Queensland, Australia

Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador

🇧🇷

Salvador, Bahia, Brazil

Crio - Centro Regional Integrado de Oncologia

🇧🇷

Fortaleza, Ceará, Brazil

Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Pernambuco

🇧🇷

Recife, Pernambuco, Brazil

Liga Norte Riograndense Contra o Câncer

🇧🇷

Natal, RIO Grande DO Norte, Brazil

ONCOSITE - Centro de Pesquisa Clinica em Oncologia

🇧🇷

Ijui, RIO Grande DO SUL, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre

🇧🇷

Porto Alegre, RIO Grande DO SUL, Brazil

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa

🇧🇷

Porto Alegre, RIO Grande DO SUL, Brazil

Hospital São Lucas da PUCRS

🇧🇷

Porto Alegre, RIO Grande DO SUL, Brazil

Centro de Pesquisa Clínica - Área Administrativa

🇧🇷

Porto Alegre, RIO Grande DO SUL, Brazil

Fundação Faculdade Regional de Medicina de São José do Rio Preto

🇧🇷

São José do Rio Preto, SÃO Paulo, Brazil

Hospital de Base de São José do Rio Preto

🇧🇷

São José do Rio Preto, SÃO Paulo, Brazil

Hospital Esperança Recife: Pronto Atendimento 24h

🇧🇷

Pernambuco, Brazil

Dr. Everett Chalmers Regional Hospital

🇨🇦

Fredericton, New Brunswick, Canada

Cape Breton Regional Hospital

🇨🇦

Sydney, Nova Scotia, Canada

Royal Victoria Regional Health Centre

🇨🇦

Barrie, Ontario, Canada

William Osler Health System

🇨🇦

Brampton, Ontario, Canada

Oakville Trafalgar Memorial Hospital

🇨🇦

Oakville, Ontario, Canada

CIUSSS- saguenay-Lac-Saint-Jean

🇨🇦

Chicoutimi, Quebec, Canada

Jewish General Hospital

🇨🇦

Montreal, Quebec, Canada

Iceg Clinic

🇨🇱

La Florida, Región Metropolitana DE Santiago, Chile

Cancer Hospital Chinese Academy of Medical Science

🇨🇳

Beijing, Beijing, China

Peking University People's Hospital

🇨🇳

Beijing, Beijing, China

Beijing Cancer hospital

🇨🇳

Beijing, Beijing, China

Chongqing University Cancer Hospital

🇨🇳

Chongqing, Chongqing, China

The First People's Hospital of Foshan

🇨🇳

Foshan, Guangdong, China

Guangdong Provincial People's Hospital

🇨🇳

Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center

🇨🇳

Guangzhou, Guangdong, China

Guangxi Medical University Affiliated Tumor Hospital

🇨🇳

Nanning, Guangxi, China

Harbin Medical University Cancer Hospital

🇨🇳

Harbin, Heilongjiang, China

The First Affiliated Hospital of Henan University of Science &Technology

🇨🇳

Luoyang, Henan, China

Henan Cancer Hospital

🇨🇳

Zhengzhou, Henan, China

Tongji Hospital Tongji Medical,Science & Technology

🇨🇳

Wuhan, Hubei, China

Hubei Cancer Hospital

🇨🇳

Wuhan, Hubei, China

Hunan Cancer Hospital

🇨🇳

Changsha, Hunan, China

The First Hospital of Jilin University

🇨🇳

Changchun, Jilin, China

The First Hospital of China Medical University

🇨🇳

Shenyang, Liaoning, China

The First Affiliated Hospital of Xi'an Jiaotong University

🇨🇳

Xi'an, Shaanxi, China

Fudan University Shanghai Cancer Center

🇨🇳

Shanghai, Shanghai, China

West China Hospital of Sichuan University

🇨🇳

Chengdu, Sichuan, China

Tianjin Medical University Cancer Institute & Hospital

🇨🇳

Tianjing, Tianjin, China

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine

🇨🇳

Hangzhou, Zhejiang, China

Zhejiang Cancer Hospital

🇨🇳

Hangzhou, Zhejiang, China

Taizhou Hospital of Zhejiang Province

🇨🇳

Taizhou, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University

🇨🇳

Wenzhou, Zhejiang, China

Rajiv Gandhi Cancer Institute And Research Centre

🇮🇳

New Delhi, Delhi, India

Kiran Hospital - Multi Super Speciality Hospital and Research Center

🇮🇳

Surat, Gujarat, India

Spandana Oncology Centre (SOC)

🇮🇳

Bangalore, Karnataka, India

Tata Memorial Hospital

🇮🇳

Mumbai, Maharashtra, India

Kims Kingsway Hospital

🇮🇳

Nagpur, Maharashtra, India

Apex Wellness Hospital

🇮🇳

Nashik, Maharashtra, India

Sahyadri Super Speciality Hospital

🇮🇳

Pune, Maharashtra, India

Bhakti Vedanta Hospital and Research Institute

🇮🇳

Thane, Maharashtra, India

GBH Memorial cancer Hospital and American International Institute of Medical sciences

🇮🇳

Udaipur, Rajasthan, India

Apollo Multispeciality Hospitals limited

🇮🇳

Kolkata, WEST Bengal, India

Soroka Medical Center

🇮🇱

Be'er Sheva, Hadarom, Israel

Rabin Medical Center

🇮🇱

Petah Tikva, Hamerkaz, Israel

Rambam Health Care Campus

🇮🇱

Haifa, Hatsafon, Israel

Shaare Zedek Medical Center

🇮🇱

Jerusalem, Yerushalayim, Israel

Aichi Cancer Center Hospital

🇯🇵

Nagoya, Aichi, Japan

Nagoya University Hospital

🇯🇵

Nagoya, Aichi, Japan

Nagoya City University Hospital

🇯🇵

Nagoya, Aichi, Japan

Chiba cancer center

🇯🇵

Chiba-shi, Chiba, Japan

National Hospital Organization Shikoku Cancer Center

🇯🇵

Matsuyama, Ehime, Japan

Gunma Prefectural Cancer Center

🇯🇵

Otashi, Gunma, Japan

National Hospital Organization Hokkaido Cancer Center

🇯🇵

Sapporo, Hokkaido, Japan

Tohoku University Hospital

🇯🇵

Sendai, Miyagi, Japan

Osaka International Cancer Institute

🇯🇵

Osaka-shi, Osaka, Japan

Osaka University Hospital

🇯🇵

Suita, Osaka, Japan

Saitama Medical University International Medical Center

🇯🇵

Hidaka, Saitama, Japan

St. Luke's International Hospital

🇯🇵

Chuo-ku, Tokyo, Japan

The Cancer Institute Hospital of JFCR

🇯🇵

Koto, Tokyo, Japan

Center Hospital of the National Center for Global Health and Medicine

🇯🇵

Shinjyuku-ku, Tokyo, Japan

Hiroshima City Hiroshima Citizens Hospital

🇯🇵

Hiroshima, Japan

Kumamoto Shinto General Hospital

🇯🇵

Kumamoto, Japan

Okayama University Hospital

🇯🇵

Okayama, Japan

National Hospital Organization Osaka National Hospital

🇯🇵

Osaka, Japan

Inha University Hospital

🇰🇷

Incheon, Incheon-gwangyeoksi [incheon], Korea, Republic of

National Cancer Center

🇰🇷

Goyang-si, Kyǒnggi-do, Korea, Republic of

CHA Bundang Medical Center, CHA University

🇰🇷

Seongnam-si, Kyǒnggi-do, Korea, Republic of

Seoul National University Bundang Hospital

🇰🇷

Seongnam, Kyǒnggi-do, Korea, Republic of

Pusan National University Hospital

🇰🇷

Busan, Pusan-kwangyǒkshi, Korea, Republic of

Seoul National University Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of

Kangbuk Samsung Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of

Severance Hospital, Yonsei University Health System

🇰🇷

Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of

Asan Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of

Gangnam Severance Hospital, Yonsei University Health System

🇰🇷

Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of

Samsung Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of

Korea University Guro Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of

Ewha Womans University Mokdong Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [seoul], Korea, Republic of

Keimyung University Dongsan Hospital

🇰🇷

Daegu, Taegu-kwangyǒkshi, Korea, Republic of

Cryptex Investigación Clínica S.A. de C.V.

🇲🇽

Cuauhtémoc, Ciudad De México, Distrito Federal, Mexico

Mexico Centre for Clinical Research S.A de C.V

🇲🇽

Mexico City, Distrito Federal, Mexico

COI Centro Oncologico Internacional S.A.P.I. de C.V.

🇲🇽

Mexico City, Distrito Federal, Mexico

Boca Clinical Trials Mexico S.C.

🇲🇽

Guadajalara, Jalisco, Mexico

Filios Alta Medicina S.A. de C.V.

🇲🇽

Monterrey, Nuevo LEÓN, Mexico

Unidad de Investigación en Salud de Chihuahua, S.C.

🇲🇽

Chihuahua, Mexico

Oaxaca Site Management Organization S.C.

🇲🇽

Oaxaca, Mexico

Instituto Veracruzano en Investigación Clínica S.C.

🇲🇽

Veracruz, Mexico

Tumor Zentrum Aarau

🇨🇭

Aarau, Aargau, Switzerland

Kantonsspital Olten

🇨🇭

Olten, Switzerland

China Medical University Hospital

🇨🇳

Taichung, Taiwan

National Cheng Kung University Hospital

🇨🇳

Tainan, Taiwan

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