Treatment of type 2 diabetes with antioxidant vitamin C therapy
- Conditions
- Type 2 diabetesskeletal muscle insulin resistanceAlternative and Complementary Medicine - Other alternative and complementary medicineMetabolic and Endocrine - Diabetes
- Registration Number
- ACTRN12614000239662
- Lead Sponsor
- Deakin University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 24
Males and females with type 2 diabetes, no major medical illness apart from T2D, aged 35-70 years
HbA1c >6.5% and <10.0%; total cholesterol <6.5mmol.L-1; triglycerides <4.0mmol.L-1; body mass index <35kg.m-2; systolic blood pressure <160mmHg; diastolic blood pressure <90mmHg; smoking, a history of cardiovascular, renal, respiratory or neurological disease; a heart murmur condition or bleeding disorder; haemochromatosis or iron overload disorders; insulin therapy, on oral anti-hyperglycaemic medications other than metformin (no greater than 2000mg total per day) or sulfonylureas and/or a dipeptidyl-peptidase-4 inhibitors; taking vitamin or herbal supplements during month prior to participation; taking medications known to influence insulin sensitivity; and if pregnant or planning a pregnancy during the trial period.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of insulin sensitivity using a euglycaemic, hyperinsulinaemic clamp coupled with the infusion of a stable glucose tracer (assessed using gas chromatography/mass spectrometry (GC/MS) methods)[Immediately before and immediately after both 4-month interventions.]
- Secondary Outcome Measures
Name Time Method Measurement of vitamin C status in skeletal muscle and plasma, measured using high performance liquid chromatography (HPLC).[Immediately before and immediately after both 4-month interventions.]