The effect of dairy-derived proteins on circulating lipids and related cardiovascular risk factors in mildly hypercholesterolaemic individuals

Not Applicable

Completed

• Conditions: hypercholesterolaemia; Diet and Nutrition - Other diet and nutrition disorders; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system

• Registration Number: ACTRN12611001013954
• Lead Sponsor: actoPharma

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-09-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

1. mild hypercholesterolaemia; fasted LDL-C > 3.0 mmol/L
2. no clinical intervention or drug treatment for hyperlipidaemia
3. no previous cardiovascular events
4. no evidence of end organ damage
5. willingness to participate in a clinical trial

Exclusion Criteria

1. allergy to milk or dairy products
2. treatment for lipid disorders
3. treatment for hypertension
4. significant metabolic disorders, including diabetes mellitus, significant renal impairment (serum creatinine>130mmol/L; EGFR<60) or other disease
5. gout
6. participation in another clinical intervention trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in fasting circulating low density lipoprotein (LDL) cholesterol concentration. Blood samples will be collected via phlebotomy for analyses[At the end of each 3 week treatment (day 21/22)]

Secondary Outcome Measures

Name	Time	Method
Changes in cardiovascular related markers including urine uric acid, blood pressure, total cholesterol, high density lipoprotein (HDL) cholesterol, triacylglyceride (TAG), glucose and insulin. Blood samples will be collected via phlebotomy for analyses.[At the end of each 3 week treatment (day 21/22)]