Urinary Tract Infection in Patients With Chronic Kidney Disease

Completed

• Conditions: Chronic Kidney Diseases; Urinary Tract Infections

• Registration Number: NCT05674942
• Lead Sponsor: Alexandria University

Brief Summary

This study aims to investigate the etiology and associated risk factors for UTI in Egyptian chronic kidney disease patients. In addition, to identify the isolated micro-organisms and their sensitivity patterns for better anticipation of treatment regimen.

Detailed Description

Chronic kidney disease (CKD) patients are at higher risk of urinary tract infections (UTI), as CKD is a state of chronic inflammation, metabolic disturbance and impaired immunocompetence. Moreover, patient with CKD are usually of advanced age and suffer from other comorbidities such as diabetes, hypertension, obesity, and cardiovascular diseases, which also add to their risk of infection.

UTI comprises heterogeneous conditions ranging from mild cystitis, easily treated with oral antibiotics, to life-threatening sepsis and multiple organ failure.

There is scarce information about risk factors of recurrence of UTI and infection with multidrug-resistant organisms in the Egyptian population.

Study Timeline

• Study First Submitted: 2022-12-14
• Study First Submitted QC: 2022-12-29
• Study First Posted: 2023-01-09
• Study Start: 2023-06-01
• Primary Completion: 2024-04-15
• Study Completion: 2024-05-15
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-15
• Last Update Posted: 2024-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

1. Males and non-pregnant females aged ≥ 18 years old
2. Patients with CKD stages (G1 to G4)
3. Patients diagnosed with UTI due to urine culture

Exclusion Criteria

1. Non-CKD patients
2. pregnant females
3. CKD patients on immunosuppressant agents
4. ESRD patients on hemodialysis
5. Patients with structural abnormalities which make them liable to frequent UTI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalence of UTI in CKD patients	records will be retrospectively screened from January 2019 till September 2022	percentage of UTI in CKD patients
isolated microorganisms causing UTI in CKD patients	records will be retrospectively screened from January 2019 till September 2022	isolated microorganisms in cultures causing UTI in CKD patients

Secondary Outcome Measures

Name	Time	Method
sensitivity pattern of urine cultures in CKD	records will be retrospectively screened from January 2019 till September 2022	describe sensitivity pattern of urine cultures in CKD

Trial Locations

Locations (1)

Faculty of Medicine, Alexandria University; 🇪🇬 Alexandria, Egypt