Urinary Tract Infection in Patients With Chronic Kidney Disease: A Retrospective Observational Study at Outpatient Nephrology Clinics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- prevalence of UTI in CKD patients
研究概览
简要总结
This study aims to investigate the etiology and associated risk factors for UTI in Egyptian chronic kidney disease patients. In addition, to identify the isolated micro-organisms and their sensitivity patterns for better anticipation of treatment regimen.
详细描述
Chronic kidney disease (CKD) patients are at higher risk of urinary tract infections (UTI), as CKD is a state of chronic inflammation, metabolic disturbance and impaired immunocompetence. Moreover, patient with CKD are usually of advanced age and suffer from other comorbidities such as diabetes, hypertension, obesity, and cardiovascular diseases, which also add to their risk of infection.
UTI comprises heterogeneous conditions ranging from mild cystitis, easily treated with oral antibiotics, to life-threatening sepsis and multiple organ failure.
There is scarce information about risk factors of recurrence of UTI and infection with multidrug-resistant organisms in the Egyptian population.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males and non-pregnant females aged ≥ 18 years old
- •Patients with CKD stages (G1 to G4)
- •Patients diagnosed with UTI due to urine culture
排除标准
- •Non-CKD patients
- •pregnant females
- •CKD patients on immunosuppressant agents
- •ESRD patients on hemodialysis
- •Patients with structural abnormalities which make them liable to frequent UTI
结局指标
主要结局
prevalence of UTI in CKD patients
时间窗: records will be retrospectively screened from January 2019 till September 2022
percentage of UTI in CKD patients
isolated microorganisms causing UTI in CKD patients
时间窗: records will be retrospectively screened from January 2019 till September 2022
isolated microorganisms in cultures causing UTI in CKD patients
次要结局
- sensitivity pattern of urine cultures in CKD(records will be retrospectively screened from January 2019 till September 2022)
研究者
Mohamed Mamdouh Mahmoud Mohamed Elsayed , MD
Assistant professor & lecturer
Alexandria University