Optimization of diAgnostic accuracy in iDiopathic inflammAtory myopathies
- Conditions
- Patients suspected of myositis
- Registration Number
- NL-OMON20832
- Lead Sponsor
- none
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
•Suspected idiopathic inflammatory myopathy
•Symmetrical proximal muscle weakness causing functional limitation
•Start of symptoms =24 months
•Indication for treatment with corticosteroids
•Minimum age of 18 years
•Patient is mentally competent
•Follow up of 6 months is possible
•Other clear cause for proximal muscle weakness, i.e. the use of myotoxic medication, high suspicion for an inflammatory neuropathy (CIDP) or a positive family history for a hereditary neuromuscular disease
•A high suspicion for sporadic inclusion body myositis (sIBM)
•High suspicion on a neurogenic cause
•Immunosuppressive treatment, with the exception of prednison up to 60mg since 2 weeks.
•Previous history of myositis
•Contraindications for MRI, claustrophobia
•No consent for muscle biopsy
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the diagnostic accuracy and patient burden of testing strategies in patients suspected for idiopathic inflammatory myopathy who qualify for treatment with corticosteroids.<br>Diagnostic accuracy will be based reference diagnosis of an expert panel.
- Secondary Outcome Measures
Name Time Method Cost-effectiveness analysis