Towards an optimal diagnostic work-up in patients suspected for idiopathic inflammatory myopathies: a diagnostic accuracy study
- Conditions
- muscle inflammationMyositis10029317
- Registration Number
- NL-OMON55232
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
In order to be eligible to participate in this study, a patient must be adult
(>=18 years of age) and suspected of an idiopathic inflammatory myopathy based
on signs and symptoms. The latter include:
• Symmetrical proximal muscle weakness causing functional limitation to justify
treatment with corticosteroids, without significant sensory abnormalities.
• Start of symptoms <=24 months
• Other clear cause for proximal muscle weakness, i.e. the use of myotoxic
medication, high suspicion for an inflammatory neuropathy (CIDP) or a positive
family history for a hereditary neuromuscular disease
• A high suspicion for sporadic inclusion body myositis (sIBM) based on
clinical symptoms, including: combination of slow onset of asymmetrically,
predominantly distal weakness, atrophy of quadriceps and forearms and age >50
years.3
• High suspicion on a neurogenic cause, based on more severe distal weakness
than proximal weakness, asymmetric weakness, fasciculations in >1 region
• No availability for follow-up of 6 months
• Immunosuppressive treatment
• Previous history of myositis
• Contraindications for MRI, claustrophobia
• No consent for muscle biopsy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method