Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Device: Effective light-emitting diode therapy; Device: Placebo light-emitting diode therapy

• Registration Number: NCT01770938
• Lead Sponsor: Universidade Federal de Sao Carlos

Brief Summary

Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, light-emitting diode therapy (LEDT) has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations in gene expression of muscle tissue as well as biochemical, biomechanic and histologic adaptations influenced by exercise associated to LEDT.

Detailed Description

This study assessed muscle performance in isokinetic dynamometry and led press device, gene expression by RT-PCR, lactate, creatine kinase and morphology of muscle tissue by immunohistochemical analysis

Study Timeline

• Study Start: 2012-05
• Primary Completion: 2012-07
• Study First Submitted: 2012-09-15
• Study First Submitted QC: 2013-01-15
• Study First Posted: 2013-01-18
• Status Verified: 2014-09
• Study Completion: 2014-09
• Last Update Submitted: 2014-09-19
• Last Update Posted: 2014-09-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

• healthy males aged between 18 and 28 years with a body mass index (BMI) equal to or less than 26 kg/m2,
• moderated pattern of physical activity

Exclusion Criteria

• previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),
• osseous or articular disorder in the lower limbs,
• cardiovascular system disorders,
• systemic disease, and
• taking prescription medicines or using dietary supplements such as muscle mass builders.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Effective light-emitting diode therapy and training	Effective light-emitting diode therapy	Effects of effective light-emitting diode therapy therapy on muscle performance of young males submitted to physical strength training
Placebo light-emitting diode therapy and training	Placebo light-emitting diode therapy	Effects of placebo light-emitting diode therapy on muscle performance of young males submitted to physical strength training

Primary Outcome Measures

Name	Time	Method
Modulations on muscle gene expression by RT-PCR	12 weeks

Secondary Outcome Measures

Name	Time	Method
Gene expression	12 weeks	Gene expression of muscle tissue by RT-PCR
Muscle performance in leg press device	12 weeks
Muscle performance in leg extension device	12 weeks
Muscle performance in isokinetic dynamometer	12 weeks

Trial Locations

Locations (1)

Federal University of São Carlos; 🇧🇷 São Carlos, São Paulo, Brazil