HMG Stimulation Versus HRT for Endometrial Preparation Prior to Blastocyst Transfer in Moderate to Severe IUA Patients
- Conditions
- Infertility, FemaleIntrauterine Adhesion
- Interventions
- Drug: human menopausal gonadotrophinDrug: hormone replacement therapy
- Registration Number
- NCT03578172
- Lead Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
- Brief Summary
Evaluation of endometrial preparation using either human menopausal gonadotrophin (HMG) stimulation and hormone replacement therapy (HRT) prior to blastocyst transfer in patients with moderate to severe intrauterine adhesion (IUA).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 186
- BMI 18~23 kg/m2
- Women with moderate to severe IUA as defined by the American Fertility Society classification (1988)
- Presence of at least 3 cryopreserved cleavage-stage embryos (including 1 good quality) or blastocysts
- Using embryos from donor oocytes
- Preimplantation genetic diagnosis(PGD)/Preimplantation genetic screening(PGS) cycles
- Moderate or severe endometriosis
- Untreated unilateral or bilateral hydrosalpinx
- Uterine adenomyosis, uterine myoma (submucous,intramural myoma >4 cm),>1cm septate uterus, double uterus, bicornuate uterus, unicornuate uterus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental-HMG stimulation group human menopausal gonadotrophin Women will be subjected to ovarian stimulation for endometrial preparation using human menopausal gonadotrophin before blastocyst transfer Control-HRT group hormone replacement therapy Women will be subjected to hormone replacement therapy for endometrial preparation before blastocyst transfer
- Primary Outcome Measures
Name Time Method Ongoing pregnancy rate 10th week after embryo transfer Ongoing pregnancy is defined as the presence of a gestational sac with foetal heartbeat by transvaginal ultrasound at 10th week after embryo transfer(ET)
- Secondary Outcome Measures
Name Time Method Cycle cancellation rate the day of embryo transfer Implantation rate 4th weeks after embryo transfer Sacs seen in early ultrasound divided by the number of embryos transferred
Clinical pregnancy rate 4th weeks after embryo transfer Number of patients with ultrasound evidence of pregnancy divided by the number of embryo transfers
Biochemical pregnancy rate 4th weeks after embryo transfer number of pregnancies with a transient elevation of serum human chorionic gonadotropin(β-hCG) level (\>10 mIU/ml) divided by number of embryo transfers
Early miscarriage rate 12th weeks gestational age Number of losses of clinical pregnancies divided by number of clinical pregnancies
Trial Locations
- Locations (1)
Reproductive & Genetic Hospital of CITIC-XIANGYA
🇨🇳Changsha, Hunan, China