Attempt to raise the pH of gastric juice during gastric ESD
Not Applicable
- Conditions
- gastric csncer
- Registration Number
- JPRN-UMIN000041299
- Lead Sponsor
- International University of Health and Welfare Hospital
- Brief Summary
There were 14 cases of post-ESD bleeding in patients treated with proton-pump inhibitors (PPIs), including oozing during second-look endoscopy compared to only 1 case of bleeding with vonoprazan administration. Vonoprazan was also associated with better post-ESD ulcer healing than PPIs. Gastric pH during ESD after vonoprazan administration on the night before gastric ESD was 6.96 in all 11 patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
Not provided
Exclusion Criteria
Exclude people who are already taking PPIs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method On the day of ESD, gastric juice is collected and measured for pH before the endoscopic procedure, and an upper gastrointestinal endoscopy is performed the day after the completion of ESD and at 2 months to confirm the size and healing of the ulcer after endoscopic treatment.
- Secondary Outcome Measures
Name Time Method