CARRIAGE study: investigating Staphylococcus aureus nasal carriage

Not Applicable

• Conditions: asal carriage of Staphylococcus aureus; Infections and Infestations

• Registration Number: ISRCTN10474633
• Lead Sponsor: niversity of Cambridge (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-20
• Last Update Posted: 13 March 2023
• Study Completion: 2026-06-27

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 22250

Inclusion Criteria

Current inclusion criteria as of 24/02/2023:

1. Be already enrolled in the INTERVAL, COMPARE or STRIDES BioResource studies
2. Have an email address for study participation
3. Reside in mainland England
4. Have a good understanding of the English language, both written and oral (study materials are not tailored to support non-English language speakers)

_____

Previous participant inclusion criteria as of 19/06/2019:

1. Be already enrolled in the INTERVAL or COMPARE studies
2. Have an email address for study participation
3. Reside in mainland England
4. Have a good understanding of the English language, both written and oral (study materials are not tailored to support non-English language speakers)

_____

Previous participant inclusion criteria:

1. Be already enrolled in the INTERVAL study
2. Have an email address for study participation
3. Reside in mainland England
4. Have a good understanding of the English language, both written and oral (study materials are not tailored to support non-English language speakers)

Exclusion Criteria

Current exclusion criteria as of 24/02/2023:

1. Received three invitations from the INTERVAL, COMPARE or STRIDES BioResource research study teams to take part in other studies in the past year
2. Withdrawn their consent to take part in the INTERVAL,COMPARE or STRIDES BioResource studies
3. Any abnormalities or ongoing medical conditions that affect the nose (e.g. nosebleeds, nasal polyps, rhinitis, etc)
4. Undergone nasal surgery in the last year
5. Nasal fracture in the last year

_____

Previous participant exclusion criteria as of 19/06/2019:

1. Received three invitations from the INTERVAL or COMPARE research study teams to take part in other studies in the past year
2. Withdrawn their consent to take part in the INTERVAL or COMPARE studies
3. Any abnormalities or ongoing medical conditions that affect the nose (e.g. nosebleeds, nasal polyps, rhinitis, etc)
4. Undergone nasal surgery in the last year
5. Nasal fracture in the last year

______

Previous participant exclusion criteria:

1. Have received 3 invitations from the INTERVAL research study team to take part in other studies in the past year
2. Have withdrawn their consent to take part in the INTERVAL study
3. Have any abnormalities or ongoing medical conditions that affect the nose (e.g. nosebleeds, nasal polyps, rhinitis, etc)
4. Have undergone nasal surgery in the last year
5. Have had a nasal fracture in the last year
6. Are not going to be available to take part in the study during the next two months due to reasons such as an extended holiday

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Current primary outcome measure as of 19/06/2019:<br><br> 1. To assess the feasibility of collecting, processing and analysing nasal swabs in large numbers of participants.<br> 2. To assess the prevalence of persistent S. aureus nasal carriage rates in healthy volunteers.<br> 3. To assess lifestyle and biomarker correlates of persistent nasal S. aureus carriage and validate associations with previously suggested candidate genetic variants and to identify new genetic associations.<br><br> _____<br><br> Previous primary outcome measure:<br><br> Response rates to nasal swab collections including differences in response rates to initial invitation to provide two vs three swabs and compliance to the collection and return of two vs three swabs<br>