Inflammation and cardiovascular morbidity in acromegaly
Recruiting
- Conditions
- acromegaly, acromegaly, inflammatie, inflammation, hartvaatziekten, cardiovasculaire ziekten, cardiovascular disease
- Registration Number
- NL-OMON27425
- Lead Sponsor
- Radboudumc Nijmegen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 240
Inclusion Criteria
In general: Subjects should be at least 18 years old and mentally competent
Exclusion Criteria
Cross-sectional part of the study
Excluded from participation in this study will be subjects who are/have:
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To examine comprehensively the role of inflammation in the pathogenesis of CV complications in acromegaly. This will be done by exploring the inflammatory profiles of patients with acromegaly and correlating these profiles with clinical parameters of atherosclerosis and CV risk factors;
- Secondary Outcome Measures
Name Time Method To investigate the role of GH/IGF-1 exposure on epigenetic reprogramming of the monocytes in patients with acromegaly;<br /><br>To investigate in vivo vascular imaging parameters as measure of systemic and vascular inflammation as well as fat infiltration;<br /><br>To investigate inflammatory markers and metabolic characteristics in muscle in order to elucidate the molecular and metabolic mechanisms governing this process;<br /><br>To investigate the contribution of genetic factors to CV morbidity in patients with acromegaly by performing whole genome association studies;<br /><br>To investigate the correlation between the gut and mouth microbiome and the CV morbidity in patients with acromegaly.