Role of extracellular calcium in inflammation in obesity or rheumatoid arthrtis

• Conditions: E66.02; M05.80

• Registration Number: DRKS00024017
• Lead Sponsor: niversität Leipzig

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-10-02
• Study Start: 2021-03-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

RA: according to ACR/EULAR-criteria 2010, DAS28 > 3.2, stabile tgherapie für 3 months, prednisolon < 7.5 mg/d, stabile dose for 1 month
- Obesity: BMI = 30 kg/m² or WHR > 0,85 (w) or > 1 (m) respectively

Exclusion Criteria

Intake of calcium-, Vitamine D-, parathormone or diuretic preparations; endocrinologic disorders, therapy with biologicals, aktive bacterial or viral infection within 2 weeks, leucocytes <3.000/mm³, hypoalbuminemia, GFR < 30 ml/min, i.a. injections within 3 months, malignant disease

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Calcium-induced IL1ß-release from MDM in cell culture tissue

Secondary Outcome Measures

Name	Time	Method
- Calcium-induced IL-1ß release in coculture of MDM with adipocytes<br>- Calcium-induced IL-1ß release in MDM with adipose tissue factors present in obesity<br>- Differences in differential blood count, lipid profile, vitamine D