The role of inflammation in the pathogenesis of tinnitus

Completed

• Conditions: ringing in the ears; Tinnitus; 10019243

• Registration Number: NL-OMON51359
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 26 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

- Adult, aged 18 years or older;
- Hearing threshold: average of 1000kHz, 2000kHz & 4000kHz <= 25 dB in both ears
- Hospital Anxiety and Depression Score (HADS), anxiety score <= 7
- HADS Depression score <= 7
- Participant has sufficient mastery of the Dutch language to fill out the
questionnaires.

Exclusion Criteria

- Objective tinnitus.
- Presence of neurological disease (apart from tinnitus)
- Presence of inflammatory disease, or the use of anti-inflammatory medication.
- Presence or history of a malignancy
- Presence of a disease of the ear (e.g. chronic otitis media, otosclerosis,
previous surgery etc).
- Presence of an coagulation disorder
- Presence of a serious psychiatric disorder.
- Pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are blood cytokine levels of TNF-a, IL-1&beta;, IL-6,<br /><br>IL-10 and IFN-&gamma;.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Complete blood count measures (neutrophil count, lymphocyte count, thrombocyte<br /><br>count, Mean Platelet Volume (MPV), Mean Corpuscular Volume (MCV), Platelet<br /><br>Distribution Weight (PDW), neutrophil-to-lymphocyte ratio (NLR) and<br /><br>platelet-to-lymphocyte ratio (PLR)). </p><br>