Thiamine deficiency in patients admitted to intensive care with sepsis and septic shock

Not Applicable

Completed

• Conditions: Sepsis; Septic shock; Infection - Other infectious diseases

• Registration Number: ACTRN12618001165279
• Lead Sponsor: Royal Adelaide Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-07-13
• Study Completion: 2018-09-16
• Last Update Posted: 22 March 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Sepsis, defined as an infection complicated by organ dysfunction, identified as SOFA score greater than or equal to 2 or a change in SOFA greater than or equal to 2 point from baseline,
OR
Septic shock, defined as sepsis and persistent hypotension despite adequate fluid resuscitation, as seen by:
1. Vasopressors required to maintain MAP greater than or equal to 65 mmHg
AND
2. Serum lactate level greater than 2 mmol/

Exclusion Criteria

<18 years of age;
Pregnancy;
Liver cirrhosis;
Thiamine supplementation commenced, in the institution, prior to, or within 24 hours of ICU admission.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thiamine deficiency, assessed by transketolase levels in blood samples[timepoints of blood draws:<br>1) at or shortly after ICU admission<br>2) 24 hours after ICU admission [primary timepoint]<br>3) 48 hours after ICU admission<br>4) 72 hours after ICU admission]

Secondary Outcome Measures

Name	Time	Method
actate level, obtained by arterial blood draw[Timepoints for lactate measurements will be:<br>1) at or shortly after ICU admission<br>2) 24 hours after ICU admission<br>3) 48 hours after ICU admission<br>4) 72 hours after ICU admission]