Thiamin deficiency and associated factors in children with transfusion-dependent thalassemia and its effect on oxidative stress
- Conditions
- Thiamin deficiency and associated factors in children with transfusion-dependent thalassemia and its effect on oxidative stressThiamin deficiency, children, transfusion-dependent thalassemia, oxidative stress
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1.Aged 7 years to less than 18 years
2.Diagnosed as transfusion-dependent thalassemia
3.Receive regular blood transfusion for at least 12 months or 10-17 times
4.Understand Thai language
5.Eligible to give information on food frequency questionnaire and record food diary
Exclusion Criteria
1. Underwent bariatric surgery, or had short bowel syndrome
2. Consume probiotics containing Bifidobacteria, Lactococcus, Leuconostoc, Lactobacillus sanfranciscensis, Lactobacillus rhamnosus strain GG that can synthesize thiamin
3. Receive diuretic drugs from other conditions
4. Post a critical illness within 1 month
5. Chronic infection, or recent infection within 2 weeks
6. Other hematologic disease
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method prevalence of thiamin deficiency at baseline thiamin pyrophosphate effect value
- Secondary Outcome Measures
Name Time Method associated factors of thiamin deficiecny at baseline Patient reported outcome using a questionnaire interview and food diary,oxidative stress at baseline malondialdehyde measurement,antioxidant at baseline total antioxidant capacity measurement,whole blood thiamin pyrophosphat (TPP)e level at baseline high performance liquid chromatography,growth status at baseline weight, height measurement and z-score calculation