Microcirculatory perfusion alterations in severe burn injury

Recruiting

• Conditions: burns; fluid resuscitation; 10014982; 10011954

• Registration Number: NL-OMON47089
• Lead Sponsor: Maasstadziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

burns TBSA>15%
(total body surface area)

Exclusion Criteria

no informed consent
suspected serious infection

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters/endpoints: Standard operating procedure for measurement<br /><br>of microcirculatory perfusion (sublingual tissues): vessel density parameters,<br /><br>microvascular flow index and flow heterogeneity will be measured on admission<br /><br>(T=0) and after 4, 8, 12 and 24 hours. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Skin perfusion maps (Laser Speckle Imaging) will be recorded. Skin perfusion<br /><br>maps will be displayed in unaffected skin and wounds of different burn depth.<br /><br>(2nd and 3rd degree burn depth) on predetermined different times.<br /><br>Blood and urine samples: Blood and urine samples will be collected at the<br /><br>certain time points to be analysed for syndecan, hyaluronic acid, heparin<br /><br>sulfate, MDA, free-Hb and Ni/Na</p><br>