Microcirculatory and macrocirculatory alterations in different thyroid states

• Conditions: cardiac function; microvasculature; 10082206; 10043739; 10003216

• Registration Number: NL-OMON40419
• Lead Sponsor: endocrinologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Patients with differentiated thyroid carcinoma who have to receive a treatment with radioactive iodine.
Has the capacity to understand and willingness to sign an informed consent form
Aged 18-80 years

Exclusion Criteria

* Other malignancy
* Clinically relevant active systemic disease (such as autoimmune or infectious diseases)
* Pregnancy
* Heart failure (New York Heart Association (NYHA) classes II, III or IV)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>changes in cardiac function (cardiac output and mean arterial bloodpressure)<br /><br>and microcirculatory function (as measured with Cytocam) in different thyroid<br /><br>states.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Capillary refill time<br /><br>• Skin-difference temperature gradient (Tskin-diff)<br /><br>• Peripheral perfusion index (PI)<br /><br>• Transthoracic cardiac ultrasound<br /><br>• Heart rate</p><br>