Microvascular changes and microvascular reactivity in stable patients with Chronic Obstructive Pulmonary Disease using non-invasive retinal imaging
- Conditions
- Chronic Obstructive Pulmonary Disease
- Registration Number
- NL-OMON26359
- Lead Sponsor
- VITO and CIRO
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 246
COPD as a primary diagnosis according to the Global Initiative For Chronic Obstructive Lung Disease (GOLD) definition: ”Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients. Its pulmonary component is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases”. COPD is diagnosed by a chest physician.
-Clinically stable on the basis of clinical picture by chest physician.
-Lack of motivation for voluntary participation in this study.
-The presence of abnormalities in the lens (e.g. cataract) or retina (e.g. retinal detachment), which makes it impossible to make an image of the retina.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence of changes in the retinal microvasculature (for example change in vessel caliber, geometric pattern, etc) in patients with COPD.
- Secondary Outcome Measures
Name Time Method -Endothelial function analyzed via reactive hyperemia, blood pressure and ankle brachial index in patients with COPD.<br /><br>-The effect of a high-intensity exercise on the reactivity of the retinal microvasculature in patients with COPD compared to non-COPD subjects (obtained in an earlier study). <br /><br>-The effect of an 8-week inpatient rehabilitation program on the retinal vessel calibers in patients with COPD. <br /><br>-The association between 1) retinal vessel changes/retinal vascular reactivity and cardiovascular phenotyping (endothelial function, blood pressure, ankle brachial index, AFR), 2) retinal vessel changes/retinal vascular reactivity and relevant outcomes for COPD patients (e.g. lung function, CAT, 6MWT, CPET, CWRT, smoking status; all included in the routine baseline assessment prior to rehabilitation) <br>