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Clinical Trials/NCT03498001
NCT03498001CompletedNot Applicable

Effects of GLP-1 Agonists on CArdiac Steatosis Evaluated by Magnetic Resonance Imaging

Centre Hospitalier Universitaire Dijon1 site in 1 country42 target enrollmentStarted: April 16, 2018Last updated:
Conditions
Interventions
Drugs

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
42
Locations
1
Primary Endpoint
Change from Baseline Concentration of intramyocardial triglycerides at 6 months

Study Overview

Brief Summary

Type II diabetes is a known risk factor for heart failure, particularly through the progressive development of diabetic cardiomyopathy. Cardiac metabolic parameters, including myocardial steatosis and epicardial fat, are altered in diabetic patients. The development of new anti-diabetics (incretins) has demonstrated protective cardiovascular effects independent of effects on glycemic control for the first time in the history of these therapies. Thus Glucagon-Like Peptide 1 (GLP-1) agonists improve the recovery of cardiac function after a heart attack and decrease atheromatous processes. It has also been demonstrated in a diabetic rat model that the administration of Liraglutide, a GLP-1 agonist, leads to normalization of myocardial steatosis associated with beneficial cardiac molecular remodeling involving pro-apoptotic, oxidative and metabolic processes. These beneficial cardiovascular effects were observed in the absence of any changes in blood glucose, insulin levels or body weight.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
50 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patient who has given his consent
  • Adult patient over 50 years of age Type II diabetic treated without modification of the antidiabetic treatment during the previous 3 months
  • HbA1c ≥ 7%.
  • Patient for whom a decision to start a GLP-1 agonist treatment has been made (Liraglutide, Semaglutide, Dulaglutide).
  • At least one risk factor from among:
  • Treated hypertension,
  • treated dyslipidemia,
  • History of obesity (BMI>30 kg/m2)
  • Active smoking (from 1 cigarette per day) or smoking cessation for less than 3 years,
  • Coronary heredity (myocardial infarction or sudden death before age 55 in father/brother, myocardial infarction or sudden death before age 65 in mother/sister)

Exclusion Criteria

  • - Protected adult Patient not affiliated to a national health insurance scheme Pregnant or breastfeeding woman Women who intend to become pregnant or of childbearing age and do not use adequate contraceptive methods.
  • Antidiabetic treatment of the incretin family (DPP4 inhibitor except sitagliptin) Severe renal failure (clearance <30ml/min according to Cockroft due to gadolinium injection) Claustrophobia / contraindication to MRI (compatible non-MRI implanted metallic material) History of hypersensitivity to gadoteric acid or gadolinium-based contrast agents and meglumine Hypersensitivity to Liraglutide, Semaglutide, Dulaglutide or any of the excipients History or presence of pancreatitis (acute or chronic) Chronic inflammatory bowel disease Diabetic gastroparesis Dysthyroidism

Arms & Interventions

Patients

Experimental

Intervention: GLP-1 agonists (Drug)

Patients

Experimental

Intervention: Cardiac MRI (Procedure)

Patients

Experimental

Intervention: Follow up by phone (Other)

Outcomes

Primary Outcomes

Change from Baseline Concentration of intramyocardial triglycerides at 6 months

Time Frame: Month 6

Intramyocardial triglyceride concentration, expressed in %, evaluated by NMR spectroscopy

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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