NCT00440141已完成4 期
Brimonidine 0.1% Versus Brinzolamide 1% as Adjunctive Therapy to Latanoprost 0.005%
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- Allergan
- 入组人数
- 40
- 主要终点
- IOP
研究概览
简要总结
Patients with glaucoma or ocular hypertension currently being treated with latanoprost 0.005%, and in need of additional IOP lowering will be randomized to receive either brimonidine 0.1% or brinzolamide 1% three-times daily as adjunctive therapy to latanoprost 0.005%
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Glaucoma or ocular hypertension in both eyes
- •Currently being treated with latanoprost 0.005% QD
- •IOP greater than or equal to 18mm Hg on latanoprost 0.005%
- •Best-corrected VA of 20/200 or better in each eye
- •Visual field within 6 months of study entry
排除标准
- •Secondary glaucoma
- •Active intraocular inflammation or macular edema
- •Intraocular surgery or laser surgery within the past 3 months
研究组 & 干预措施
1
Experimental
干预措施: latanoprost 0.005% eye drops and brimonidine 0.1% eye drops (Drug)
2
Active Comparator
干预措施: latanoprost 0.005% eye drops and brinzolamide 1.0% eye drops (Drug)
结局指标
主要结局
IOP
时间窗: Month 3
次要结局
- Tolerability(Month 3)
研究者
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终止
4 期
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已完成
不适用
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