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Latanoprost

Generic Name
Latanoprost
Brand Names
Iyuzeh, Rocklatan, Xalacom, Xalatan, Xelpros, Catiolanze
Drug Type
Small Molecule
Chemical Formula
C26H40O5
CAS Number
130209-82-4
Unique Ingredient Identifier
6Z5B6HVF6O

Overview

Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as Timolol. Another benefit latanoprost is that it can be administered once a day.

Background

Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as Timolol. Another benefit latanoprost is that it can be administered once a day.

Indication

Latanoprost is indicated for the reduction of elevated intraocular pressure in patients who have been diagnosed with open-angle glaucoma or ocular hypertension. It is available as monotherapy or in a combination product with netarsudil or timolol. In Canada, latanoprost is also indicated to treat elevated intraocular pressure due to angle-closure glaucoma that has been treated with peripheral iridotomy or laser iridoplasty.

Associated Conditions

  • Increased Intra Ocular Pressure (IOP)
  • Ocular Hypertension
  • Open Angle Glaucoma (OAG)

FDA Approved Products

LATANOPROST
Manufacturer:DIRECT RX
Route:OPHTHALMIC
Strength:50 ug in 1 mL
Approved: 2020/01/20
NDC:61919-112
Rocklatan
Manufacturer:Alcon Laboratories, Inc.
Route:OPHTHALMIC, TOPICAL
Strength:0.05 mg in 1 mL
Approved: 2020/06/02
NDC:70727-529
XELPROS
Manufacturer:Sun Pharmaceutical Industries, Inc.
Route:OPHTHALMIC, TOPICAL
Strength:0.05 mg in 1 mL
Approved: 2021/02/10
NDC:47335-317
Latanoprost
Manufacturer:A-S Medication Solutions
Route:OPHTHALMIC
Strength:50 ug in 1 mL
Approved: 2022/06/30
NDC:50090-1920
Tim-Lat -PF
Manufacturer:ImprimisRx NJ
Route:OPHTHALMIC
Strength:0.05 mg in 1 mL
Approved: 2018/05/08
NDC:70261-517

Singapore Approved Products

XALATAN EYE DROPS 0.005%
Manufacturer:PFIZER MANUFACTURING BELGIUM NV
Form:SOLUTION
Strength:50 mcg/ml
Online:Yes
Approved: 1997/11/21
Approval:SIN09549P
XALACOM EYE DROPS
Manufacturer:PFIZER MANUFACTURING BELGIUM NV
Form:SOLUTION
Strength:50mcg/ml
Online:Yes
Approved: 2002/05/11
Approval:SIN11922P
LATOCHEK STERILE EYE DROPS 0.005%
Manufacturer:Indoco Remedies Limited
Form:SOLUTION, STERILE
Strength:0.05mg/ml
Online:Yes
Approved: 2016/02/19
Approval:SIN14956P
LATANDROPS EYE DROPS SOLUTION 50mcg/ml
Manufacturer:VIANEX SA
Form:SOLUTION
Strength:0.050 mg
Online:Yes
Approved: 2014/08/15
Approval:SIN14590P
LANOTAN OPHTHALMIC SOLUTION 0.005% w/w
Manufacturer:BAUSCH & LOMB INCORPORATED (TAMPA)
Form:SOLUTION
Strength:0.005% w/w
Online:Yes
Approved: 2013/08/27
Approval:SIN14399P

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