Optic Nerve Head Perfusion Following Treatment with Latanoprost 0.005% Versus Brimionidin Tartrate 0.2% in Primary Open Angle Glaucoma: an Optical Coherence Tomography Angiography Study
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- OPTIC NERVE PERFUSION using OCT angiography numerical analysis system presented in %
研究概览
简要总结
This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently diagnosed with bilateral primary open angle glaucoma equally divided into two groups with 28 patients in each group
详细描述
This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently diagnosed with bilateral POAG equally divided into two groups with 28 patients in each group. The whole VD was increased and also increased in all four nasal, temporal, superior, and inferior quadrants around optic disc from the initial vessel density before treatment (p<0.001) in both groups significantly with superior improvement in group (1) compared to group (2) that was statistically significant
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age more than 18 years newly diagnosed naive patients with POAG
排除标准
- •optic nerve lesions other than glaucomatous changes patients with previous glaucoma surgery
研究组 & 干预措施
Latanoprost (Xalatan)
Group (1) included 23 patients (46 eyes) treated with Latanoprost 0.005 %
干预措施: Latanoprost (Xalatan) (Drug)
Brimonidine 0.2%
24 patients (48 eyes) received treatment with Brimonidin tartrate 0.2% in group (2)
干预措施: Brimonidine 0.2 % (Drug)
结局指标
主要结局
OPTIC NERVE PERFUSION using OCT angiography numerical analysis system presented in %
时间窗: 3 months
perfusion of optic nerve head in patients with primary open angle glaucoma (POAG) using optical coherence tomography angiography (OCTA).
次要结局
未报告次要终点