High-flow Nasal Cannula Nebulization of Beta 2 Adrenergic Agonist During Acute Exacerbation of Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 3 期
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- compare lung functions
研究概览
简要总结
High-flow nasal cannula is an oxygenation technique increasingly used for patients admitted for acute respiratory failure. Literature essentially concerns "de novo" acute hypoxemic failure and the interest of high-flow during take care of chronic obstructive pulmonary disease patients is few studied. Physiological studies reported potential benefits of high-flow nasal cannula oxygenation in chronic obstructive pulmonary disease patients including dead space clearance and decrease of respiratory, which lead to decrease work of breathing. As inhaled bronchodilators are part of treatment of chronic obstructive pulmonary disease exacerbation, nebulization could be also provided through high-flow nasal cannula oxygen therapy. The aim of our study is to determine whether a beta-2 agonist nebulization administered through High-flow nasal cannula is efficient to improve spirometry of patients for admitted hronic obstructive pulmonary disease exacerbation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Arterial pH over 7.25,
- •Respiratory rate under 35 breaths/mn
- •Glasgow Coma Scale equal to 15,
- •indication of beta-2 agonist nebulization less than 8 per day (time between two nebulization more than 3 hours),
- •NIV sessions spaced more than 6 hours.
排除标准
- •Urgent endotracheal intubation;
- •Contraindication to beta 2 adrenergic agonist;
- •Another organ failure (hemodynamic and neurological instability);
- •Cardioselective beta-blocker during treatment of copd exacerbation;
研究组 & 干预措施
TREATMENT
salbutamol nebulization
干预措施: salbutamol (Drug)
结局指标
主要结局
compare lung functions
时间窗: baseline-1h30
Evolution of Forced Expiratory Volume 1s
次要结局
未报告次要终点