Invasive Measurement of Positive Tracheal Pressure Generated by High Flow Nasal Oxygen Administration in Critically Ill Patients After Extubation: a Physiologic Study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- HFNC-PEEP
研究概览
简要总结
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.
It acts generating a mild positive pressure in the airways and by reducing respiratory effort of patients.
However to the best of our knowledge, no study to date has directly measured the amount of positive pressure generated in the trachea of patients.
The primary aim, therefore, of this study measures this positive pressure after extubation in critically ill patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CRITICALLY ILL PATIENTS AFTER MECHANICAL VENTILATION LASTED AT LEAST 72 HOURS
- •age 18-80 years
排除标准
- •COPD stage >1 according to GOLD classification
- •end stage organ disease (liver, kidney, heart, lung)
- •neuromuscular disease
- •previous tracheostomy
- •obesity with BMI > 35 Kg/m2
- •non collaborative patient
结局指标
主要结局
HFNC-PEEP
时间窗: 3 HOURS
THE LEVEL OF POSITIVE AIRWAY PRESSURE GENERATED BY DIFFERENT FLOW RATES OX OXYGEN WILL BE RECORDED. FLOW RATE STARTS AT 10 L/MIN AND IT WILL BE INCREASED A 10 L/MIN STEP EVERY 30 MINUTES UNTIL 60 L/MIN.
次要结局
- HFNC-EADI(3 HOURS)
研究者
Cristian Deana
Medical Doctor, Anesthesiologist and Critical Care Physician
Azienda Sanitaria-Universitaria Integrata di Udine