Invasive Measurement of Positive Tracheal Pressure Generated by High Flow Nasal Oxygen Administration in Critically Ill Patients After Extubation: a Physiologic Study.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Respiratory Failure
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- HFNC-PEEP
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.
It acts generating a mild positive pressure in the airways and by reducing respiratory effort of patients.
However to the best of our knowledge, no study to date has directly measured the amount of positive pressure generated in the trachea of patients.
The primary aim, therefore, of this study measures this positive pressure after extubation in critically ill patients.
Investigators
Cristian Deana
Medical Doctor, Anesthesiologist and Critical Care Physician
Azienda Sanitaria-Universitaria Integrata di Udine
Eligibility Criteria
Inclusion Criteria
- •CRITICALLY ILL PATIENTS AFTER MECHANICAL VENTILATION LASTED AT LEAST 72 HOURS
- •age 18-80 years
Exclusion Criteria
- •COPD stage \>1 according to GOLD classification
- •end stage organ disease (liver, kidney, heart, lung)
- •neuromuscular disease
- •previous tracheostomy
- •obesity with BMI \> 35 Kg/m2
- •non collaborative patient
Outcomes
Primary Outcomes
HFNC-PEEP
Time Frame: 3 HOURS
THE LEVEL OF POSITIVE AIRWAY PRESSURE GENERATED BY DIFFERENT FLOW RATES OX OXYGEN WILL BE RECORDED. FLOW RATE STARTS AT 10 L/MIN AND IT WILL BE INCREASED A 10 L/MIN STEP EVERY 30 MINUTES UNTIL 60 L/MIN.
Secondary Outcomes
- HFNC-EADI(3 HOURS)