Long-term Outcome Followed-up of the Cognitive Disorders After General Anesthesia
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Cognitive ability
研究概览
简要总结
Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 10 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with informed consents
- •Without basal disorders of neurology and psychiatrics
排除标准
- •With the history of cognitive disorders
- •With chronic neurological disorders
- •Cannot communicate with investigators
- •Cannot stand general anesthesia
研究组 & 干预措施
Inhalational anesthesia
Patients received sevoflurane anesthesia during general anesthesia
干预措施: Sevoflurane (Drug)
Intravenous anesthesia
Patients received intravenous anesthetic (Propofol) during general anesthesia
干预措施: Propofol (Drug)
结局指标
主要结局
Cognitive ability
时间窗: The 10th year since postoperation
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
次要结局
- Cognitive ability(Once a year from the 1st year after operation up to 9th year)
研究者
Fu Zhou Wang
Dr
Nanjing Medical University