Long-term Outcome Followed-up of the Cognitive Disorders After General Anesthesia
Trial Snapshot
- Phase
- Phase 4
- Sponsor
- Enrollment
- 10,000
- Locations
- 1
- Primary Endpoint
- Cognitive ability
Study Overview
Brief Summary
Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Outcomes Assessor)
Eligibility Criteria
- Ages
- 10 Years to 80 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with informed consents
- •Without basal disorders of neurology and psychiatrics
Exclusion Criteria
- •With the history of cognitive disorders
- •With chronic neurological disorders
- •Cannot communicate with investigators
- •Cannot stand general anesthesia
Arms & Interventions
Inhalational anesthesia
Patients received sevoflurane anesthesia during general anesthesia
Intervention: Sevoflurane (Drug)
Intravenous anesthesia
Patients received intravenous anesthetic (Propofol) during general anesthesia
Intervention: Propofol (Drug)
Outcomes
Primary Outcomes
Cognitive ability
Time Frame: The 10th year since postoperation
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
Secondary Outcomes
- Cognitive ability(Once a year from the 1st year after operation up to 9th year)
Investigators
Fu Zhou Wang
Dr
Nanjing Medical University