NCT00392275已完成4 期
Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 6
- 主要终点
- Aqueous levels of antibiotics
研究概览
简要总结
Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.
详细描述
The purpose of this study is to assay human aqueous for concentrations of ofloxacin, ciprofloxacin and levofloxacin after topical or combined topical and oral administration in eyes with filtering blebs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with functioning filtering blebs will be evaluated prospectively for inclusion
排除标准
- •Any subject who is already scheduled to have cataract surgery performed will qualify for participation with the exception of the following exclusion criteria:
- •Ongoing ocular inflammatory disease
- •Bleb leakage - determined by Seidel test
- •Suspected infection
- •Known contraindications to use of any of these study medications.
- •Pregnancy
结局指标
主要结局
Aqueous levels of antibiotics
次要结局
未报告次要终点
研究者
研究点 (6)
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