Trauma-focused therapy in people at risk of psychosis

Not Applicable

Completed

• Conditions: Psychosis; Mental and Behavioural Disorders; Unspecified organic or symptomatic mental disorder

• Registration Number: ISRCTN31976295
• Lead Sponsor: niversity of Bristol

Brief Summary

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33004398/ protocol (added 07/10/2020) 2024 Results article in https://doi.org/10.1192/bjo.2024.57 (added 25/06/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2018-05-03
• Study Completion: 2021-05-31
• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

1. Those aged 16 years or over who are at risk of psychosis (as defined in the Comprehensive Assessment of At-Risk Mental States (CAARMS) (A. R. Yung et al., 2005)
2. Presence of at least one positive symptom (perceptual abnormality, unusual thought, or non-bizarre ideas) scored =3 on CAARMS
3. History of traumatic experience as defined in ICD-10 F43.1, occurring prior to onset of first positive symptom
4. Presence of 1 or more symptoms of re-living, avoidance, hyper-arousal, or cognitive distortions in relation to the traumatic experience (assessed using the PTSD Checklist for DSM-V (PCL5) during the last month (Bovin et al., 2016))

Exclusion Criteria

1. People with past history of treated or untreated psychotic illness or learning disability
2. Current use of antipsychotics
3. Currently receiving psychological therapy
4. Completed a trauma-focused psychological therapy in the last 2 years
5. Insufficient fluency in English
6. Lacking mental capacity to provide valid informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Transition to psychosis assessed at 12 months post-randomization from clinical records (measured as an ICD-10 diagnosis of psychosis) or, if patients have dropped out of the Early Intervention Services, researchers will invite participants for an appointment where, via the CAARMS, it will be established whether they transitioned to psychosis.