Incidence of CTEPH in Dependence of Thrombus Location in Patients With Acute Pulmonary Embolism and Index Fibrinolysis
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- CTEPH
研究概览
简要总结
Chronic thromboembolic pulmonary hypertension (CTEPH) has been associated with increased morbidity and mortality. Patients with pulmonary embolism (PE) have elevated risk for development of CTEPH. It is not known, whether the location of pulmonary embolism (central vs. peripheral) nor fibrinolysis have an impact of CTEPH incidence. This study has been performed to assess the CTEPH incidence in different populations: in patients with central vs. peripheral PE and in patients with or without fibrinolysis therapy for PE.
详细描述
The embolus localization during index pulmonary embolism might be of potential relevance for CTEPH development.
In the present study patients with confirmed pulmonary embolism for at least 12 months will be screened for CTEPH. The incidence of CTEPH will be correlated to thrombus location (central vs. peripheral) and the index use of fibrinolysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute pulmonary embolism for at least 12 months
排除标准
- •known pulmonary hypertension other than CTEPH
结局指标
主要结局
CTEPH
时间窗: participants will be followed at least one year after acute pulmonary embolism, an expected average of 5 years follow-up is estimated
Incidence of CTEPH
次要结局
未报告次要终点
研究者
Dr. Fikret Er
MD
University of Cologne