Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism

• Conditions: CTEPH

• Registration Number: NCT01672203
• Lead Sponsor: University of Cologne

Brief Summary

Chronic thromboembolic pulmonary hypertension (CTEPH) has been associated with increased morbidity and mortality. Patients with pulmonary embolism (PE) have elevated risk for development of CTEPH. It is not known, whether the location of pulmonary embolism (central vs. peripheral) nor fibrinolysis have an impact of CTEPH incidence. This study has been performed to assess the CTEPH incidence in different populations: in patients with central vs. peripheral PE and in patients with or without fibrinolysis therapy for PE.

Detailed Description

The embolus localization during index pulmonary embolism might be of potential relevance for CTEPH development.

In the present study patients with confirmed pulmonary embolism for at least 12 months will be screened for CTEPH. The incidence of CTEPH will be correlated to thrombus location (central vs. peripheral) and the index use of fibrinolysis.

Study Timeline

• Study Start: 2009-01
• Status Verified: 2012-08
• Study First Submitted: 2012-08-15
• Study First Submitted QC: 2012-08-23
• Last Update Submitted: 2012-08-23
• Study First Posted: 2012-08-24
• Last Update Posted: 2012-08-24
• Primary Completion: 2012-10
• Study Completion: 2012-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• acute pulmonary embolism for at least 12 months

Exclusion Criteria

• known pulmonary hypertension other than CTEPH

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CTEPH	participants will be followed at least one year after acute pulmonary embolism, an expected average of 5 years follow-up is estimated	Incidence of CTEPH

Trial Locations

Locations (1)

Heart Center of the University Hospital of Cologne; 🇩🇪 Cologne, NRW, Germany