Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension : PROTEO-CTEPH Study.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Proteomic pattern associated with the diagnosis of Chronic thromboembolic pulmonary hypertension (CTEPH)
研究概览
简要总结
Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE). CTEPH is evoked in patients with persistent dyspnea. According to international guidelines, symptomatic patients with perfusion defects on lung scan and Pulmonary Hypertension (PH)-likely transthoracic echo (TTE) must be evaluated in Pulmonary Hypertension (PH)-centers with right heart catheterism, to confirm or rule out the presence of precapillary Pulmonary Hypertension (PH), and precise the group of Pulmonary Hypertension (PH).
详细描述
However, persistent dyspnea and perfusion defects are frequent after pulmonary embolism (PE), and the accuracy of transthoracic echo (TTE) is not great for precapillary Pulmonary Hypertension (PH).
This study proposed to seek for a specific proteomic pattern in patients admitted for a suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations)
- •Patients who require a right heart catheterization.
- •Patient affiliated or entitled to a social security plan
- •Patient having received informed information about the study informed about the study
排除标准
- •Patient with a normal perfusion lung scan
- •Person under legal guardianship
研究组 & 干预措施
Patient with suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH)
- right cardiac catheterization (usual practice)
- a blood sample (inclusion for all patients with suspicion)
- if diagnosis of Chronic thromboembolic pulmonary hypertension confirmed a another bood sample at 6 months
干预措施: blood sample (Biological)
结局指标
主要结局
Proteomic pattern associated with the diagnosis of Chronic thromboembolic pulmonary hypertension (CTEPH)
时间窗: Day: 0
Analysis of the final diagnosis retained for the patient : Chronic thromboembolic pulmonary hypertension (CTEPH) (population of interest), pre-capillary Pulmonary Hypertension (PH) other than Chronic thromboembolic pulmonary hypertension (CTEPH), post-capillary Pulmonary Hypertension (PH), no Pulmonary Hypertension (PH).
次要结局
- Analysis of recording of hemodynamic data at diagnosis(Day: 0)
- Analysis of recording of hemodynamic data at diagnosis and at death(6 months)
- Analysis of recording of hemodynamic after 6 months of treatment(6 months)